IiNdawo zokuNyanga iTumor (TTFields) zivunyiwe ukuba zinomhlaza wePancreatic

Iiseli zomhlaza zineendawo ezitshajiswa ngombane ngoko ke ziphenjelelwa ziintsimi zombane. Ukusetyenziswa kweentsimi zombane ezitshintshanayo (iiTTFields) kwiithumba eziqinileyo kukhetha ukujolisa nokuphazamisa i-mitosis kumanqanaba ahlukeneyo ekwahlulweni kweeseli zomhlaza, kuphucula ukhuseleko lomzimba oluchasene nethumba kunye nokunciphisa impendulo yomonakalo we-DNA ekhokelela ekufeni kweeseli zomhlaza. Uvavanyo lweklinikhi lubonise ukuba unyango lwe-TTFields luphucula amazinga okusinda kwe-glioblastoma, i-mesothelioma kunye namatyala omhlaza wemiphunga angengoweseli encinci esasazekayo ngoko ke unyango lwe-TTFields lwavunywa kunyango lwale meko yomhlaza ngaphambili. Ngoku, nge-12 kaFebruwari 2026, ngokusekelwe kwiziphumo zovavanyo lweklinikhi lwakutshanje, i-FDA ivumile unyango lwe-TTFields lomhlaza we-pancreatic ophucukileyo kwindawo. Oku kubalulekile kuba ulawulo lweklinikhi lomhlaza we-pancreatic lunzima ngenxa yokubikezela okubi kunye nenqanaba lokusinda eliphantsi.  

Iindawo zombane ezitshintshiselanayo, ezaziwa ngokuba ziiTumour Treating Fields (TTFields), eziziswa sisixhobo esiphathekayo sokuvelisa intsimi yombane esingangenisi ntsholongwane, zivunyiwe ukuba zisetyenziswe kunyango lomhlaza wepancreatic ophucukileyo kubantu abadala. 

I-Optune Pax, isixhobo esiphathwayo esenziwe ngu I-Novocure yayiyi yavunywa ukuba inyangwe umhlaza wepancreatic ophucukileyo nge-12 kaFebruwari 2026 yi-FDA ngokusekelwe kwiziphumo zovavanyo lweklinikhi lwesigaba sesi-3 olubonise ukuba ukongezwa kwe-TTFields kwi-chemotherapies esemgangathweni yokhathalelo i-gemcitabine kunye ne-nab-paclitaxel (GnP) kuphucule ukusinda kwayo yonke into malunga neenyanga ezimbini xa kuthelekiswa ne-GnP yodwa. Esi sixhobo sasifumene uphawu lweBreakthrough Device ngaphambili ngoDisemba 2024.  

Unyango lwe-Tumour Treatment Fields (TTFields) lunyango lomhlaza olungangenisi ntsholongwane. Lusebenzisa intsimi yombane ethile ye-sinusoidal ukusuka kwi-100 kHz ukuya kwi-300 kHz, ephazamisa ukwahlukana kweeseli zomhlaza ngokukhawuleza kwaye ibangele ukufa kweeseli ngelixa iiseli eziphilileyo zihlala zingachaphazeleki. Lunyanyezelwa kakuhle zizigulana kwaye lufunyaniswe luphucula ukusinda kwazo zonke izigulana ezineethumba eziqinileyo.  

I-TTFields sele ivunyiwe impatho umhlaza we-glioblastoma multiforme (GBM) osandul’ ukuxilongwa nophindaphindayo, i-malignant pleural mesothelioma (MPM) kunye nomhlaza wemiphunga ongengoweseli encinci osasazekayo. Umhlaza we-pancreatic oqhubele phambili apha ekhaya ngowona wamva nje kuluhlu.  

Umhlaza wepancreatic sisifo esibi kakhulu esinesifo esinganyangekiyo kwaye sihlala ixesha elide. Sesinye sezona zifo zomhlaza zinzima ukunyanga. Ukuvunywa kweTTFields kwiSigaba sesiThathu somhlaza wepancreatic ophucukileyo apha ekhaya kunika izigulane ukhetho olutsha lonyango.  

*** 

Iingxelo:  

1. I-FDA News Release – I-FDA Ivuma Isixhobo Esiphambili Sohlobo Lwaso Sokunyanga Umhlaza Wepancreatic. Iposiwe nge-12 kaFebruwari 2026. Iyafumaneka apha https://www.fda.gov/news-events/press-announcements/fda-approves-first-its-kind-device-treat-pancreatic-cancer  
2. I-Babiker HM okqhubekayo 2025. Iintsimi Zonyango Lweethumba NgeGemcitabine kunye neNab-Paclitaxel kwi-Adenocarcinoma yePancreatic ePhambili: Uphononongo lwePANOVA-3 oluQhelekileyo, oluVulekileyo, oluPhambili. J Clin Oncol 43, 2350-2360(2025) Umqulu 43, Inombolo 21. DOI: https://doi.org/10.1200/JCO-25-00746 
3. Isiphumo seMimandla yokuNyanga iTumor (TTFields, 150 kHz) njengoNyango lwangaphambili lwePancreatic Adenocarcinoma ephuculweyo apha ekhaya ehambelana neGemcitabine kunye neNab-paclitaxel (PANOVA-3). NCT03377491. Iyafumaneka apha https://clinicaltrials.gov/study/NCT03377491?tab=study 
4. UServenti JN kunye noNewton HB, 2025. Iinkalo Zonyango Lweethumba: Unyango Olutsha lweGlioblastoma kunye nezinye iithumba Eziqinileyo. I-JADPRO Umqulu 16, Inombolo 5 (Septemba/Okthobha 2025). I-DOI: https://doi.org/10.6004/jadpro.2025.16.5.3 
5. ULi, uXing nabanye ngo-2023. Uphononongo lweenkalo zonyango lwe-tumor (TTFields): ukuqhubela phambili kwizicelo zeklinikhi kunye nokuqonda koomatshini. I-Radiology kunye ne-Oncology Umqulu 57 (2023): Ingxaki 3 (Septemba 2023), DOI: https://doi.org/10.2478/raon-2023-0044 
6. UShams S. kunye noPatel CB, 2022. Iindlela zokulwa nomhlaza zesenzo sonyango olutshintshanayo lweendawo zombane (iindawo zonyango lwe-tumor [TTFields]). Ijenali yeBiology yeMolecular Cell, uMqulu 14, Inqaku 8, Agasti 2022, mjac047. I-DOI: https://doi.org/10.1093/jmcb/mjac047 

***

Indlela yokusebenza yeTTFields