Imiphumo yokungaphelelanga bekukubi (umzekelo kwi mars) kwinkqubo yethu yezihlunu isaqondwa ngokuyinxenye. Uphononongo kwiimpuku lubonisa ukuba i-resveratrol, ikhompawundi efumaneka kwisikhumba somdiliya kunye newayini ebomvu, inokunciphisa ukonakala kwemisipha mars nxalenye bekukubi imodeli. Oku kunokuba luncedo ukugcina ixesha elide mars ubufundisi.
INational Aeronautics noLawulo lweNdawo (NASA) yase-USA iceba ukuthumela oosomajukujuku eNyangeni kunye mars. I-Microgravity yaziwa ngokuchaphazela inkqubo yezihlunu zomzimba wethu njengoko imisipha aze amathambo aqale ukuba buthathaka. Okokuqala, izihlunu ezinobunzima ezifana ne-soleus, ezibekwe etholeni ziyachaphazeleka kuze emva koko kuphulukane nemicu yezihlunu ezicothayo. eMars umxhuzulane ngama-40 ekhulwini kuphela oMhlaba ngoko ke unomxhuzulane osezantsi we-0.38g. Ayikaqondwa ngokupheleleyo indlela enjalo umxhuzulane inokuchaphazela imizimba yethu. Akukho modeli inobunzima obuthile iye yavavanywa ukuza kuthi ga ngoku enokulinganisa umxhuzulane weMartian. Ukuqonda okungakumbi kule ndawo kubalulekile ukuze kucwangciswe uthumo lweendawo ezide mars kunye nokubuyela ngokukhuselekileyo koosomajukujuku eMhlabeni.
Uphononongo olutsha olupapashwe ngoJulayi 18 ngo Imida yePhysiology isebenzise iimodeli zezilwanyana ezinobunzima obungagqibelelanga eziye zaphuhliswa mars umxhuzulane oyinxalenye yokuqonda ukuba ukunqunyulwa kwemisipha kunokujongwa njani ixesha elide mars imisebenzi yendawo. Ukulinganisa ubunzima be mars, iimpuku zazifakelwe amaqhina apheleleyo aza axhonywa kwisilingi yazo. Ukwahlulwe ngamaqela amabini, iimpuku zavezwa kumthwalo oqhelekileyo (womhlaba) okanye i-40 yepesenti yokulayishwa mars iiveki ezi-2. Isiqingatha senani leempuku kwiqela ngalinye elifunyenweyo resveratrol (RSV) - i-polyphenol ekhuselekileyo edla ngokufumaneka kwisikhumba somdiliya, iwayini ebomvu kunye neblueberries - emanzini okanye emanzini kuphela. Izilwanyana zondla ngokukhululekile kwi-chow diets.
In mars imeko, ukubamba kweempuku kwaba buthathaka kwaye ukujikeleza kwethole lazo, ubunzima bezihlunu kunye nomxholo wefayibha ezicothayo uye washwabana. I-Calf circumference kunye ne-front and paw paw grip force ilinganiswe ngeveki ngelixa izihlunu zethole zihlalutywa emva kweeveki ze-2. Iziphumo zibonise ukuba i-dose yemihla ngemihla ephakathi (i-150 mg / kg / ngosuku) ye-resveratrol yabonwa ukugcina ubunzima bemisipha kunye namandla kwizilwanyana ezivezwe kwimiphumo ye-simulated mars umxhuzulane. I-RSV incede ukubuyisela imilenze yangaphambili nasemva kunye nokukhusela ubunzima bemisipha ngaphakathi mars impuku ngelixa ingenasiphumo kwisidlo okanye ubunzima bomzimba. I-RSV iyaziwa ngokuba ne-anti-inflammatory, anti-oxidative kunye ne-anti-diabetic effects. Kuye kwaboniswa ukukhuthaza ukukhula kwemisipha kwizilwanyana ezinesifo seswekile ngokunyusa uvakalelo lwe-insulin kunye nokunyuka kwe-glucose kwimicu yemisipha. Oosomajukujuku bacingelwa ukuba baphuhlisa uvakalelo lwe-insulin ngexesha lemishini yasemajukujukwini.
I-Resveratrol ibonakala inempembelelo yokukhusela imisipha njengoko igcina ithambo kunye nemisipha. Uphononongo lwangoku lubonisa ukuba i-resveratrol inokunceda ukunciphisa ukukhubazeka kwemisipha kwi-a mars i-analog yomxhuzulane oyinxenye elinganisa mars okusingqongileyo. Ingasetyenziselwa njengesongezelelo sesondlo sokunciphisa i-muscle kunye ne-skeletal deconditioning kunye nokuwohloka kwexesha elide. mars ubufundisi.
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{Unokufunda iphepha lokuqala lophando ngokunqakraza ikhonkco le-DOI elinikwe ngezantsi kuluhlu lwemithombo ecatshulweyo (s)}
Umthombo (s)
Mortreux, M. 2019. Idosi yemihla ngemihla eModareyithiweyo ye-Resveratrol iNciphisa ukuQinisekiswa kwezihlunu kwi-Martian Gravity Analog. Ngaphambili. Physiol.
https://doi.org/10.3389/fphys.2019.00899
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