Uphononongo lwakutsha nje luqikelele ukuba rhoqo kwezifo ze-herpes simplex virus (HSV) usulelo kunye nesifo sesilonda sesini (GUD). Uqikelelo lubonisa ukuba malunga ne-846 yezigidi zabantu abaneminyaka eyi-15-49 iminyaka bephila nosulelo lwe-herpes yangasese ngo-2020, engaphezulu kwe-20% yabantu abakweli qela lobudala kwihlabathi jikelele. Ukuthelekisa, inani labantu abanosulelo lwe-herpes yangasese ngo-2016 lalimalunga nesiqingatha sebhiliyoni. Amazinga aphezulu eziganeko kunye nokuxhaphaka kunye nokukhula konyaka kwiminyaka yamuva nje kufuna amanyathelo okuthintela asebenzayo. Okwangoku, alukho isitofu sokugonya se-HSV esinelayisensi. Baninzi abagqatswa bogonyo lwe-HSV abakwimibhobho kodwa bonke bakwimo yangaphambi kweklinikhi, kodwa bangene kwisigaba soku-1 solingo lwezonyango lwabantu.
I-Herpes simplex virus (HSV) yintsholongwane ye-DNA enemisonto ephindwe kabini yosapho lwe-herpesviridae. Ibophelela ekubambeni ii-receptors zeselula kwaye iphindaphinde kwizicubu ezahlukeneyo ezifana neeseli ze-epithelial, i-neurons, njl. Usulelo lusasazeka ngokudibana kwesikhumba.
Usulelo lwe-HSV luthatha ubomi bonke, luyanyangeka kodwa alunyangeki.
I-HSV ineentlobo ezimbini. I-HSV-1 ikakhulu ibangela i-herpes yomlomo kwaye isasazeka ngoqhagamshelwano lomlomo, nangona kunjalo inokubandakanyeka kwakhona kusulelo lwangasese kwaye isasazeke ngesondo.
I-HSV-2 ibangela i-herpes yangasese kwaye isasazeka ngoqhagamshelwano lwezesondo. Isifo sesilonda sesini (GUD) sinxulunyaniswa nazo zombini i-HSV-2 kunye ne-HSV-1.
Abantu abachatshazelwe lusulelo lwe-HSV, ngakumbi i-HSV-2 basemngciphekweni omkhulu wokufumana intsholongwane kaGawulayo (human immunodeficiency virus) (HIV).
Usulelo lwe-Herpes simplex virus luyaziwa ukuba luchaphazele inani elikhulu labantu kwihlabathi liphela. Ngo-2016, uphando luqikelele inani labantu abanjalo. Kwafunyaniswa ukuba malunga nesiqingatha sebhiliyoni yabantu babenosulelo lwangasese olubalelwa kwi-HSV-2 kunye ne-HSV-1 ngelixa abantu abaninzi beebhiliyoni bechatshazelwe lusulelo lomlomo ngenxa ye-HSV-1. Ngokubhekele phaya, izigidi zabantu abachaphazelekileyo babesemngciphekweni wokufumana i-human immunodeficiency virus (HIV).
Uphononongo lwakutshanje olupapashwe nge-10 kaDisemba 2024 lukhanyise ubungakanani bale ngxaki. Lusebenzisa imodeli yezibalo elinganisiweyo kunye neengeniso zemodeli ezivela kuphononongo olucwangcisiweyo kunye nohlalutyo lwe-meta-analyses lwedatha yokuxhaphaka kwe-HSV kuzo zonke iingingqi ze-WHO, olu phononongo luvelise uqikelelo lokuxhaphaka kunye nokuxhaphaka kosulelo lwe-HSV lwangasese kwihlabathi liphela ngo-2020 kwiqela leminyaka eli-15-49 ubudala, isifo sesilonda sangasese (i-GUD) esibangelwa ziintlobo ze-HSV kunye nosulelo olungelulo lwangasese olubangelwa yi-HSV-1.
Itheyibhile: Ukuphindaphinda kwezifo zosulelo lwe-HSV yangasese ngo-2020 kwiqela leminyaka eyi-15-49.
| Inani labantu abadala Iminyaka emi-15-49 achatshazelwa lusulelo lwe-HSV lwangasese kwihlabathi liphela kwi unyaka 2020 |
| Usulelo lwe-HSV lwangasese ngenxa ye-HSV-2: →I-25.6 yezigidi zamatyala amatsha (iziganeko), →519.5 yezigidi (okanye 13.3%) zizonke iimeko ezikhoyo (ukuxhaphaka) →I-187.9 yezigidi kunye nesiqendu esinye se-HSV-attributable Genital ulcer disease (GUD) ye-HSV-2 |
| Usulelo lwe-HSV lwangasese ngenxa ye-HSV-1: →I-16.8 yezigidi zamatyala amatsha (iziganeko) →376.2 yezigidi (okanye 10.2%) zizonke iimeko ezikhoyo (ukuxhaphaka) →I-16.7 yezigidi kunye nesiqendu esinye se-HSV-attributable Genital ulcer disease (GUD) ye-HSV-2 |
| →I-846 yezigidi lilonke inani labantu abaneminyaka eyi-15-49 iminyaka abaphila nosulelo lwe-herpes yangasese (ukuxhaphaka kwe-HSV-2 kunye nokuxhaphaka kwe-HSV-1). Oku kungaphezulu kwama-20% abantu abakweli qela lobudala kwihlabathi jikelele. →I-204.6 yezigidi linani lilonke labantu abaneminyaka eyi-15-49 iminyaka ubuncinane kunye nesiqendu esinye se-HSV-enokuthiwa yi-GUD →Malunga ne-42 yezigidi zabantu bafumana usulelo olutsha lwe-herpes yangasese ngonyaka. |
| (Umthombo: Harfouche M., okqhubekayo 2024) |
Njengoko kuphononongo lwakutsha nje, lilonke 846 million abantu abaneminyaka 15-49 iminyaka bephila nosulelo herpes zangasese (ngenxa HSV-2 kunye HSV-1) ngonyaka 2020. Ukuthelekisa, ngo-2016, malunga nesiqingatha sebhiliyoni abantu (kuyo yonke iminyaka yobudala) yayinosulelo lwe-herpes yangasese.
Ngokucacileyo, usulelo lwe-HSV lwangasese luneziganeko eziphezulu kakhulu kunye namazinga okuxhaphaka. Ngo-2020, ngaphezulu kwe-20% yabantu abakwiqela leminyaka eli-15-49 kwihlabathi jikelele babenosulelo lwe-herpes yangasese. Okukhathazayo kukuba, amanani aye anda ngesantya esiphezulu kule minyaka yakutshanje.
Le meko ifuna amanyathelo okuthintela nawonyango asebenzayo ngakumbi . Okwangoku, akukho gonyo le-HSV elinelayisenisi. Kukho abantu abaninzi abafanele bagonywe yi-HSV kodwa bonke bakwimeko yangaphambi konyango, kodwa abakangeni kwisigaba soku-1 sovavanyo lwezonyango ebantwini.
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Iingxelo:
- I-WHO. Iphepha lenyani - intsholongwane yeHerpes simplex. 10 Disemba 2024. Ifumaneka apha https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus
- UJames, uCharlotte et al. "Intsholongwane yeHerpes simplex: ukuxhaphaka kosulelo lwehlabathi kunye noqikelelo lwezehlo, ngo-2016." Bulletin yoMbutho wezeMpilo weHlabathi vol. 98,5 (2020): 315-329. Ifumaneka e https://pmc.ncbi.nlm.nih.gov/articles/PMC7265941/
- Harfouche M., et al 2024. Uqikelelo lwezehlo zehlabathi nezengingqi kunye nokuxhaphaka kwentsholongwane ye-herpes simplex usulelo kunye nesifo sesilonda sangasese ngo-2020: uhlalutyo lwemathematika. Izifo ezosulelayo ngokwabelana ngesondo, iijenali zeBMJ. Ipapashwe kwi-Intanethi kuQala: nge-10 kaDisemba 2024. DOI: https://doi.org/10.1136/sextrans-2024-056307
- WHO iindaba- Over 1 5 abadala ehlabathini lonke usulelo herpes zangasese - WHO. Ithunyelwe nge-11 kuDisemba 2024. Iyafumaneka e https://www.who.int/news/item/11-12-2024-over-1-in-5-adults-worldwide-has-a-genital-herpes-infection-who
- I-WHO. Ugonyo, uGonyo kunye neBiologicals – Herpes Simplex Virus. Ifumaneka e https://www.who.int/teams/immunization-vaccines-and-biologicals/diseases/herpes-simplex-virus
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 infections and genital ulcer disease (GUD). The estimates suggest that about 846 million people aged 15–49 years were living with genital herpes infections in 2020, which is more than 20% of the people in this age group globally. For comparison, total number of people with genital herpes infection in 2016 was about half a billion. High rates of incidence and prevalence and annual growth in the recent years calls for more effective preventive measures. Currently, there are no licensed HSV vaccine. There are several HSV vaccine candidates in the pipeline however all are in preclinical state, yet to enter the phase 1 of human clinical trial.){kind=link}