Abaphandi bafumanise ukuba inkumbulo kwiinkawu ezindala iphucukile emva kokunikwa iprotheyini yeKlotho enedosi ephantsi. Kungokokuqala ukuba ukubuyisela amanqanaba e-klotho kubonakaliswe kuphucula ukuqonda kwisilwanyana esingengomntu. Oku kuvula indlela yokuba uvavanyo lwezonyango kwixesha elizayo luvavanye ukuba unyango lwe-klotho lunokuba lonyango na kubantu abadala abane-dementia ngenxa yesifo se-Alzheimer (AD).
I-Klotho yiproteni yendalo . Iveliswa kakhulu kwizintso kwaye ikhona ngeendlela ezintathu. I-Membrane I-Klotho ibandakanyeka ekwaluphaleni nasekuphuhlisweni kwezifo ezingapheliyo. I-Klotho ekhutshiweyo isebenza njenge-humoral factor kwaye ikhusela amalungu omzimba ngelixa uhlobo lweproteni ye-Klotho ngaphakathi kwiseli ithintela ukukhula kweseli. Ibizwa ngokuba yi-Longevity factor ngenxa yemisebenzi yayo yebhayoloji yokulwa nokwaluphala.
Amanqanaba okujikeleza kweproteni yeKlotho ayafa ngokukhula kweminyaka. Uphononongo olwenziwe kwizilwanyana ngo-2015 lubonise ukuba iimpuku ezinenqanaba eliphantsi leKlotho ziye zakhawuleza ukwaluphala ngelixa amanqanaba aphezulu eKlotho aphucula ubomi 1. Iziphumo ezifanayo zifunyenwe kolunye uphando olubikwe kunyaka ofanayo kwiimpuku ze-human amyloid precursor protein (hAPP) transgenic – ukwanda kokubonakaliswa kweproteni yeKlotho kunciphisa ukufa kwangaphambi kwexesha kunye nokungasebenzi kakuhle kwenethiwekhi ye-neural 2. Olu vavanyo lwezilwanyana lubonise ukuba amanqanaba eproteni yeKlotho adlala indima ebalulekileyo ekwaluphaleni nto leyo ebaluleke kakhulu kwisifo esixhaphakileyo se-neurodegenerative esibizwa ngokuba sisifo se-Alzheimer (AD).
Ubudlelwane beKlotho nesifo se -Alzheimer (AD) buvele ngokusesikweni kuphononongo olucwangcisiweyo kunyaka ophelileyo. Olu phononongo lubandakanye izigulana ezingama-243 ezinesifo se-Alzheimer (AD) kunye nezilawuli ezisempilweni ngokwengqondo. Kufunyaniswe ukuba amanqanaba eKlotho kwi-Cerebro-spinal fluid (CSF) aphezulu kakhulu phakathi kwezilawuli ezisempilweni. Abantu abane- dementia ngenxa yesifo se-Alzheimer babenamanqanaba aphantsi eKlotho CSF. Ngaphezu koko, amanqanaba eKlotho ahlukile kumanqanaba eklinikhi esifo se-Alzheimer 3.
Ngaba ukubuyisela amanqanaba eKlotho kubantu abane -dementia ngenxa yesifo se-Alzheimer kungaba yindlela yokunyanga nokuthintela ezo ngxaki? Oku kunokwenzeka kuphela emva kokuba kwenziwe uvavanyo lweklinikhi kwaye iziphumo zokhuseleko nokusebenza kakuhle zifunyenwe zanelisa. Kodwa kufikelelwe kwinqanaba elibalulekileyo koku kwi-primate engengomntu.
Kwisifundo sesi -4 esabikwa ngomhla wesi-03 kuJulayi 2023, abaphandi bafumanise ukuba inkumbulo kwinkawu esele ikhulile yaphucuka emva kokunikwa iprotheyini yeKlotho enedosi ephantsi. Kungokokuqala ukuba ukubuyisela amanqanaba e-klotho kubonakaliswe kuphucula ukuqonda kwinkawu engeyomntu. Oku kuvula indlela yokuba uvavanyo lweklinikhi luvavanye ukuba unyango lwe-klotho lunokuba luncedo na kubantu abalupheleyo.
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Iingxelo:
- UKim J. okqhubekayo 2015. Indima ye-Biological ye-Anti-aging Protein Klotho. Ijenali yeLifestyle Medicine 2015; 5:1-6 . Ipapashwe kwi-intanethi ngoMatshi 31, 2015; DOI: https://doi.org/10.15280/jlm.2015.5.1.1
- I-Dubal DB okqhubekayo. 2015. I-Life Extension Factor I-Klotho iNqanda ukufa kunye nokuphucula ukuqonda kwi-hAPP Transgenic Mice. Ijenali ye-Neuroscience 11 February 2015, 35 (6) 2358-2371; DOI: https://doi.org/10.1523/JNEUROSCI.5791-12.2015
- Grøntvedt GR okqhubekayo 2022. Umbutho wamanqanaba eProtheyini yeKlotho kunye ne-KL-VS Heterozygosity Nge-Alzheimer Disease kunye ne-Amyloid kunye neTau Burden. JAMA Netw Vula. 2022;5(11):e2243232. DOI: https://doi.org/10.1001/jamanetworkopen.2022.43232
- Castner, SA, Gupta, S., Wang, D. okqhubekayo. Ubomi obude beklotho bongeza ukuqonda kwiiprimates ezindala ezingengobantu. Nat Ukuguga (2023). https://doi.org/10.1038/s43587-023-00441-x
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