Abaphandi baye benza i-2-dimensional mineral nanoparticles ukuhambisa unyango emzimbeni wokuvuselelwa kwe-cartilage.
I-Osteoarthritis sisifo esiwohlokayo esichaphazela abantu abazizigidi ezingama-630 kwihlabathi liphela, phantse i-15 ekhulwini labantu bonke emhlabeni . Kwi-osteoarthritis, i-cartilage emathanjeni ethu iqala ukuwohloka kwaye oku kunokonakalisa ithambo elingaphantsi okubangela iintlungu nokuqina, ingakumbi kumalungu edolo, esinqeni nasemilenzeni. Ukwanda kwesi sifo kuyanda njengoko sikhula. Unyango lwe-osteoarthritis luquka amayeza, i-physiotherapy, unyango lomsebenzi olujolise kakhulu ekunciphiseni iimpawu zentlungu. Ukunyanga le meko ngokupheleleyo, izicubu zamalungu ezonakeleyo kufuneka zilungiswe. Olu lungiso luyinkimbinkimbi kwaye lunzima njengoko izicubu ze-cartilage emathanjeni kunzima ukuzivuselela. Njengoko uluntu lwehlabathi lukhula, unyango olutsha olusebenzayo lwe-osteoarthritis lufuneka ngoko nangoko.
Izinto ezibangela ukukhula kweproteni
Unyango olunokwenzeka lwe-osteoarthritis lubandakanya uyilo kunye nokuhanjiswa kweendlela zonyango zeproteni oko kukuthi, iiproteni ezenziwe elebhu ukuze zisetyenziswe kunyango. Iindlela zonyango zeproteni zibe nefuthe elikhulu kwizifo ezininzi kwiminyaka yakutshanje. Olunye udidi olunjalo lweeproteni lubizwa ngokuba zii-growth factors ezizii-soluble secreted proteins . Umzimba wethu unako ukuziphilisa kwaye le nkqubo inokuphuculwa ngokusetyenziswa kwezinto zokukhula ngendlela engeyiyo ukuphucula iinkqubo ezibandakanyeka ekuziphiliseni. Nangona kunjalo, uninzi lwezinto zokukhula ezaziwayo ziyaqhekeka ngokukhawuleza kwaye ke ngoko kufuneka idosi ephezulu kakhulu ukuze kufezekiswe isiphumo sonyango. Izifundo zibonise iziphumo ezimbi zedosi ephezulu njengokudumba kunye nokwakheka kwezicubu ezingalawulwayo. Ukusetyenziswa kwezinto zokukhula nako kunqongophele kakhulu ngenxa yokunqongophala kweenkqubo zokuhambisa ezisebenzayo okanye abathwali bezinto eziphilayo. Izinto zokukhula kunye neenkqubo zokuhambisa izinto eziphilayo ezisebenzayo zibalulekile kunyango lokuvuselela olubandakanya ukulungiswa kunye nokuvuselelwa kwezicubu.
Unyango olutsha lwe-osteoarthritis esekwe kwi-nanosilicates
Abaphandi kwiYunivesithi yaseTexas A&M, eMelika bajonge ukuphuhlisa unyango olutsha lokuvuselela i-cartilage ngokuyila ii-nanoparticles zeminerali ezinemilinganiselo emibini (2D) ezinokusetyenziselwa ukukhupha izinto zokukhula. Ezi nanoparticles (okanye ii-nanosilicates) zineempawu ezimbini ezibalulekileyo - indawo ephezulu kunye ne-dual charge - ezivumela ukunamatheliswa lula kwezinto zokukhula. Ii-nanosilicates zibonisa ukusebenza okuphezulu kokubopha kwizinto zokukhula ngaphandle kokuchaphazela ukwakheka kwe-3D yeproteni okanye umsebenzi wayo webhayoloji. Zivumela ukuhanjiswa okuhlala ixesha elide (ngaphezulu kweentsuku ezingama-30) kwezinto zokukhula kwiiseli ze-mesenchymal stem zabantu ezithi emva koko zisetyenziswe ekuvuseleleni i-cartilage ngokukhuthaza ukwahlukana okuphuculweyo kweeseli ze-stem ukuya kwi-cartilage. Ukwahlukana okuphuculweyo kuqinisekisa umsebenzi ophezulu weproteni ekhutshiweyo kwaye oko kukwizinga eliphantsi eliphindwe kalishumi xa kuthelekiswa nonyango lwangoku olusebenzisa idosi ephezulu kakhulu.
Olu phononongo olupapashwe kwi -ACS Applied Materials & Interfaces lubonisa inkqubo eyenziwe nge-nanoengineered - iqonga elisekwe kwi-nanoclay apho ii-nanosilicates zingasetyenziswa njengesithuthi sokuhambisa ukuze kuvunyelwe ukuhanjiswa okuqhubekayo kwezonyango zeproteni zokunyanga i-osteoarthritis. Inkqubo enjalo yokuhambisa esekelwe kwi-biomaterial inokuqinisekisa unyango olusebenzayo lwe-osteoarthritis ngokunciphisa iindleko zizonke kunye nokunciphisa iziphumo ebezingalindelekanga. Eli qonga litsha lokuhambisa linokunyusa amaqhinga okuvuselela amathambo akhoyo kwaye libe nefuthe kunyango lokuvuselela.
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Umthombo (s)
UCross LM et al 2019. Ukuhanjiswa okuzinzileyo nokude kweProtein Therapeutics ezivela kwi-Two-Dimensional Nanosilicates. Izixhobo ezisetyenzisiweyo ze-ACS kunye nee-Interfaces. 11. https://doi.org/10.1021/acsami.8b17733
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Amagqabantshintshi zivaliwe.