UVavanyo loMchamo wokuFumana kwangethuba loMhlaza weLung 

Abaphandi baye baphuhlisa uvavanyo lomchamo olunokufumanisa umhlaza wemiphunga kwangethuba besebenzisa indlela entsha. Isebenzisa uphononongo lweprotheyini etofwayo ukubona ubukho beeseli zencindi emiphungeni nangona isebenzisana neprotheyini ethile ekujoliswe kuyo (ekhutshwe ziiseli zencindi kwizicubu zemiphunga). Ukuqokelelwa kweeseli ze-senescent kwi-tissue kuyaziwa ukuba inxulunyaniswa nokuvela komhlaza. Okwangoku, uvavanyo lukwinqanaba lokugqibela lolingo lwangaphambili kwimodeli yeempuku kwaye kufuneka luqhubele phambili kulingo lwezonyango lomntu kwakamsinyane. Uvavanyo lunokwenziwa ngokwezifiso ukuze lubonwe kwangoko ezinye iintlobo zomhlaza kwaye lunakho ukuphucula "ukuxilongwa komhlaza kwangethuba" ngesiphumo esingcono sesigulana kunye noxilongo.  

Umhlaza wemiphunga uhlala ungabonisi naziphi na iimpawu eziqaphelekayo kwizigulana ukuba zikhalaze kwaye zifune uncedo lwezonyango de unwenwele emiphungeni okanye kwamanye amalungu omzimba. Yi  

ngokuqhelekileyo kufunyenwe isifo kamva emva kokuba sele iqalile ukukhula kwaye isasazeka. Izixhobo zophando ezifana ne-histo-pathology kunye ne-CT / MRI scanners zisetyenziswa xa izigulane zinika ingxelo koogqirha abaneempawu ezidla ngokwenzeka kamva. Yiyo loo nto kungabikho ungenelelo lonyango kwangethuba. Oku kuthetha ukuba i-prognosis embi kwizigulane ezininzi. Oku kungatshintsha kwixa elizayo. Kusenokuba lula ukubona iimeko zomhlaza wemiphunga kwangethuba kusetyenziswa uvavanyo olulula lomchamo.  

Abaphandi basebenzela ukufumanisa kwangoko umhlaza wemiphunga ngovavanyo olulula lomchamo olusekwe ekuchongeni iiseli zesenescent okanye ezindala.   

Iiseli ze-senescent (ezikwabizwa ngokuba ziiseli ze-zombie) ayizoseli ezifileyo, kodwa azikwazi ukukhula kwaye zahlule ngendlela eqhelekileyo iiseli eziphilayo. Xa ezi seli ziqokelelana kwindawo enye, zilungisa imeko-bume yazo ngendlela yokuba kube lula ukuba iiseli ezinomhlaza zikhule kwaye zahlukane ngokungalawulekiyo. Kuyaziwa ukuba izicubu ezichaphazelekayo zitshintsha ngaphambi kokuvela komhlaza. Iiseli zesenescent zikhupha imiqondiso ephinda ilungelelanise izicubu kwaye ziyenze igqibelele kuphuhliso lomhlaza.  

Iprotheni ethile ekhutshwe ziiseli zesenescent kwizicubu zemiphunga ichongiwe. Le yiprotheyini yokuqhawula i-peptide efumaneka kugxininiso oluphezulu kubukho beeseli zencindi kwaye ivela kumanqanaba okuqala omhlaza. Uvavanyo lubandakanya ukufumanisa le proteni kwisampulu yomchamo wesigulane. Uvavanyo oluqinisekileyo luthetha ubukho beeseli ezisemiphunga emiphungeni ezinokuthi zibangele umhlaza emiphungeni ethubeni.  

Uvavanyo lusebenzisa iprotein probe okanye inzwa. Xa itofwe emzimbeni, iprobe icandwa ibe ziingceba ezibini yiprotheyini ekujoliswe kuyo (ekhutshwe ziiseli zeseli). Inxalenye encinci yeprobe ikhutshwe kumchamo owenziwe wabonakala kwisampulu yomchamo ngokutshintsha umbala ngokudibanisa isisombululo sesilivere. Utshintsho kumbala wesampulu yomchamo lucebisa ubukho beeseli zeseli emiphungeni nto leyo ebonisa utshintsho olunokukhokelela kumhlaza.  

Olu vavanyo lomchamo olusekwe kwiprotheyini lufumanisa iimpawu zokuqala zomhlaza wemiphunga phambi kokuphuhliswa kwesifo. Ithintela imfuno yeenkqubo ezihlaselayo kwaye yenza ukungenelela kwangoko kwonyango kunokwenzeka kwiziphumo ezingcono zesigulane kunye ne-prognosis.  

Iiprotein probes zinokuqashwa ukwenza iimvavanyo zomchamo zezinye iintlobo zomhlaza ngokunjalo.  

Uvavanyo lunokwenziwa ngokwezifiso ukuba lufunyanwe kwangethuba lweminye imihlaza kwaye lunamandla okuguqula “ukuxilongwa komhlaza kwangethuba” ngeziphumo ezingcono zesigulana kunye noxilongo. 

Umchamo ubonisa iimeko ze-pathological. Uhlalutyo olucokisekileyo lomchamo lubonisa oko kwenzekayo emzimbeni. Ke ngoko, iimvavanyo zomchamo zenziwa ngokwesiqhelo kuphando lwezonyango kubandakanya ukuxilongwa kweminye imihlaza esekwe ekubhaqweni kweeseli ezinomhlaza okanye iDNA kwiiseli zethumba (njengakwimeko yomhlaza wesinyi) okanye iDNA engenaselseli (cfDNA) okanye iDNA eguqulweyo ephalazwe bubuchopho. iiseli ithumba xa besifa (njengakwimeko glioma, uhlobo ithumba ebuchotsheni).  

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Iingxelo:  

1. Uphando lomhlaza e-UK. Iindaba - Uvavanyo lomchamo lokuqala kwihlabathi lomhlaza wemiphunga luchonga iiseli 'zezombie'. 6 Disemba 2024  

2. Uphando lomhlaza e-UK. Iindaba - Uvavanyo lomchamo lomhlaza wesinyi: Yeyiphi eyokugqibela? 16 Aprili 2022.  

3. Uphando lomhlaza e-UK. Iindaba - Izazinzulu ziphuhlisa umchamo kunye novavanyo lwegazi ukubona amathumba ebuchotsheni. 23 Julayi 2021.  

4. Uphando lomhlaza e-UK. Iindaba - Uvavanyo lomchamo lomhlaza wesinyi luyaphuhliswa. 2 Julayi 2021.  

5. Uphando lomhlaza e-UK. Iindaba - Iimvavanyo zomchamo: ukufumanisa umhlaza kumchamo. 21 Novemba 2019.  

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