Uphononongo lubonisa unyango olutsha oludityanisiweyo lweekhompawundi ezimbini ezithathwe kwisityalo ukubuyisela umva ukonakala kwengqondo kwiimpuku.
Ubuncinci abantu abazizigidi ezingama-50 bahlala nabo Isifo se-Alzheimer kwihlabathi jikelele. Inani elipheleleyo lezigulane ze-Alzheimer's disease lingadlula i-152 yezigidi nge-2050. Iimpawu zokuqala zokuphazamiseka kwengqondo kwi-Alzheimer's disease (AD) izigulane ziingxaki zememori kunye nokuphazamiseka kokuthatha izigqibo. Njengoko isifo siqhubela phambili, izigulane zifumana ukulahlekelwa kwememori ebalulekileyo kunye nobunzima bokuqonda. Alukho unyango lwe-Alzheimer's kwaye akukho ndlela yokuyeka okanye ukucothisa ukuqhubeka koku isifo. Amachiza alinganiselweyo kunye nolunye ukhetho lukhona olunokuphelisa ezinye iimpawu. Kwisifo se-Alzheimer, iiplagi ze-amyloid ziqokelelana phakathi kwee-neurons kwingqondo yezigulane. Kubantu abasempilweni, protein amaqhekeza abizwa ngokuba yi-amyloid beta protein iyaqhekeka kwaye isuswe. Kodwa xa kunjalo IAlzheimerEzi ziqwenga ziqokelelana ukuze zenze amacwecwe e-amyloid aqinileyo, anganyibilikiyo anegalelo kuthintelo lokuhanjiswa kwempembelelo kwiineurons kwaye abangele iimpawu ezilandelayo ze-amyloid. IAlzheimer isifo.
Kwiphononongo epapashwe kuyo Journal of Biological Chemistry, abaphandi baye babonisa ukuba indibaniselwano unyango inokubuyisela umva iimpawu zesifo sika-Alzheimer kwiimpuku ezazinofuzo lokukhula IAlzheimer. Iikhompawundi ezimbini ezithembisayo eziphuma kwizityalo ziye zaphononongwa ezineempawu ezincomekayo ze-amyloidogenic, okokuqala i-EGCG (epigallocatechin-3-gallate) icandelo elibalulekileyo leti eluhlaza kwaye okwesibini i-FA (i-asidi ye-ferulic) ekhoyo kwiitumato, irayisi, i-oats kunye neminqathe. Iikhompawundi zendalo ezinjalo zendalo zibizwa ngokuba 'zizondlo-zondlo' - iikhompawundi ezinyamezeleka kakuhle izongezo zendalo, ezineempawu ezifana neziyobisi kwaye zinokudityaniswa ngokulula kukutya komntu.
Uhlalutyo, iimpuku ezingama-32 zine IAlzheimer iimpawu ezinje zaye zabelwa ngokwamaqela amane. Iqela ngalinye linenani elilinganayo leenkunzi neemazi kunye neempuku ezisempilweni. Xa iimpuku zineenyanga ezili-12 ubudala, zazinikwa nokuba (a) EGCG kunye ne-FA (b) EGCG okanye i-FA okanye (c) i-placebo kanye yonke imihla kangangeenyanga ezi-3. Idosi enikezelweyo yayiyi-30 mg ngekhilogram yobunzima bomzimba njengoko le dosi inyamezeleke kakuhle ngabantu kwaye inokusetyenziswa njengenxalenye yesongezelelo sokutya okunempilo. Ngaphambi nangemva kolu lawulo lokutya olukhethekileyo, abaphandi baqhuba iimvavanyo ze-neuropsychological ezinokuhlalutya ukucinga kunye nememori kwaye ke benze uhlolo malunga nesifo. Olunye lovavanyo olwenziwayo kuvavanyo lwenkumbulo yaba 'yimaze emile ngo-Y' enokuvavanya inkumbulo yendawo yokusebenza yempuku ngokufana nomntu ekufumaneni indlela yokuphuma kwisakhiwo. Iimpuku nge IAlzheimer iimpawu ezinje azikwazi ukuhamba kwimayizi ngokulula xa kuthelekiswa noogxa abasempilweni.
Emva kokulawulwa kokutya okukhethekileyo kweenyanga ezintathu, iimpuku zine IAlzheimer njengeempawu ezenziwe ngokufana neempuku ezisempilweni ekufundeni nakwiimvavanyo zenkumbulo. Oku kucebise ukuba unyango oludityanisiweyo lwe-EGCG-FA lubuyisela umva ukonakala kwengqondo kwiimpuku IAlzheimer njengeempawu. Iimpuku eziphathwe ngokudityaniswa kwe-EGCG-FA zibonise ubuninzi obuncitshisiweyo beeprotheni ze-amyloid-beta xa zithelekiswa nonyango olulodwa lwezi khompawundi. Indlela esisiseko inokuba kukukwazi kwezi khompawundi ukuthintela iiproteni ze-amyloid ezingaphambili ukuba zingaqhekeki zibe ngamaqhekeza amancinci eprotheyini - i-amyloid beta - ethi iqokelele IAlzheimer ingqondo yesigulane njengama-plaques. I-EGCG kunye ne-FA kunye zehlise i-neuroinflammation kunye noxinzelelo lwe-oxidative engqondweni - zombini ezi ziyinxalenye ebalulekileyo ye-Alzheimer's ebantwini. Uphando oluphumeleleyo kwiimpuku alunakuguqulelwa ebantwini kodwa ezo zinto ziphuma kwisityalo okanye izongezo zinika isithembiso esibalulekileyo kunyango lwe-Alzheimer's ebantwini.
Olu phando luyimpumelelo kwiimpuku lusenokuvula indlela yolingo lwabantu. Ezo zinto zithathwe kwizityalo okanye izongezo zinika isithembiso esibalulekileyo kunyango lwe-Alzheimer.
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{Unokufunda iphepha lokuqala lophando ngokunqakraza ikhonkco le-DOI elinikwe ngezantsi kuluhlu lwemithombo ecatshulweyo (s)}
Umthombo (s)
Mori T et al. 2019. Unyango oludibeneyo kunye ne-phenolics (-) -epigallocatechin-3-gallate kunye ne-ferulic acid iphucula ukuqonda kunye nokunciphisa i-Alzheimer-like pathology kwiigundane. Journal of Biological Chemistry. 294(8). http://dx.doi.org/10.1074/jbc.RA118.004280
