Kuyilwe ipilisi entsha ehambisa i-insulin egazini ngokulula kwaye ngaphandle kweentlungu, kwiihagu okwangoku
Insulin i-hormone ebalulekileyo efunekayo ukuphula iswekile yegazi - i-glucose - ukukhusela izifo ezingaphezulu. Kuba iswekile ifumaneka kuninzi lokutya esikutyayo kubandakanya iicarbohydrates, ubisi, iziqhamo njl njl, i-insulin iyafuneka yonke imihla ukulawula iswekile yegazi. Izigulane ze iswekile bafuna inaliti ye-insulin yemihla ngemihla njengoko i-pancreas yabo ingakwazi ukuvelisa le hormone ngokwaneleyo. Ukuba ayiphathwanga, iswekile kunokubangela ezininzi impilo iingxaki ezifana nentliziyo kunye nomonakalo wezintso.
Ipilisi entsha ye-insulin
Ukuthatha iinaliti ezifakwe esiswini ibe yindlela eqhelekileyo yokuthatha i-insulin ngaphezu kwenkulungwane. Esona sizathu sesokuba uninzi lwamachiza anjenge-insulin xa luthathwa ngomlomo aluphili kuhambo lwethu esiswini namathumbu ukuya kuthi ga kwigazi kwaye ke ukutofa ngokuthe ngqo egazini yeyona ndlela ilungileyo. Iqela labaphandi elikhokelwa yi-Massachusetts Institute of Technology, eU.SA lijolise ekufumaneni enye indlela yokuthatha amayeza ngenye indlela efuna inaliti kuphononongo lwabo olupapashwe kwi. inzululwazi. Baye baphuhlisa i-capsule yechiza elingana ne-ertyisi enokunikezela ithamo lomlomo ye-insulin kwizigulana ze Uhlobo lwe-1 sikashukela. Ipilisi enjalo inokuphelisa ukusetyenziswa kwenaliti ye-insulin yemihla ngemihla.
Uyilo lobugcisa
I-capsule yeziyobisi inenaliti encinci enye eyenziwe nge-insulin ecinezelweyo ethi itofwe ngokuzenzekelayo emva kokuba i-capsule isetyenzisiwe kwaye ifike esiswini. Incam yale naliti iqulathe i-100 yeepesenti ecinezelweyo, i-insulin eyomisiweyo ekhenkcezisiweyo ngelixa i-shaft yenziwe ngezinto zepolymer ezibolayo kunye nentwana yentsimbi ecocekileyo njengoko ingangeni esiswini. I-capsule yenzelwe ngendlela ecacileyo ukwenzela ukuba incam yenaliti ihlale ikhomba kwi-tissue yangaphakathi yesisu evumela ukujova okujoliswe kuyo. Kwakhona, nayiphi na intshukumo efana nokugquma kwesisu ayinakuchaphazela ukuqhelaniswa kwe-capsule. Bakufezekisile oku ngokusebenzisa umfuziselo wokubala ngokudala ukwahluka koyilo lwemilo okuvumela ukuhlengahlengiswa kokusingqongileyo okuguquguqukayo kwesisu. Inaliti ifakwe kwi-spring ecinezelweyo ebanjwe yidiski yeswekile.
Emva kokuba ipilisi iginyiwe, i-disk disk iyancibilika ngokukhawuleza xa idibana nejusi yesisu esiswini, ikhupha intwasahlobo kwaye isebenze njengesixhobo sokujova inaliti kudonga lwesisu. , izigulana aziyi kuva nantoni na eyenza unikezelo lungabi nantlungu kwaphela. Nje ukuba incam yenaliti itofwe kudonga lwesisu, incam ye-microneedle eyenziwe nge-insulin eyomileyo iyanyibilika ngesantya esilawulwayo. Kwisithuba seyure enye, yonke i-insulin ikhutshwa egazini. Abaphandi bajonge ukuphepha naluphi na ukuhanjiswa ngaphakathi kwesisu njengoko i-asidi yesisu iphula uninzi lwamachiza ngokukhawuleza.
Uvavanyo kwiihagu
Uvavanyo lokuqala kwiihagu luqinisekisile ukuhanjiswa kwe-200 micrograms ye-insulin kwaye kamva i-5milligrams eyanele ukuthoba amanqanaba eswekile yegazi kwaye inokuthelekiswa nenaliti ye-insulin chwetheza 2 iswekile izigulane. Emva kokuba lo msebenzi ugqityiwe, i-capsule idlula kwinkqubo yokugaya ngaphandle kokubangela nayiphi na imiphumo emibi.
Abaphandi basebenzisana neDanish pharmaceutical Nova Nordisk, abona baboneleli abakhulu be-insulin kunye nabababhali abasebenzisanayo kolu phononongo, ukwenza ezi capsules kulingo lwabantu oluza kuqhutywa kwiminyaka emithathu ezayo. kwaye uqinisekise ukuhanjiswa kwedosi.Ukuba le pilisi yenzelwe ngempumelelo umntu, iinaliti ze-insulin zemihla ngemihla ziya kuba yinto edlulileyo kwaye oku kuya kuba luncedo kakhulu kwizigulane, ngakumbi abantwana aboyika iinaliti. Indlela yepilisi ilungele ngakumbi, iyaphatheka kwaye iphantsi kweendleko.
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{Unokufunda iphepha lokuqala lophando ngokunqakraza ikhonkco le-DOI elinikwe ngezantsi kuluhlu lwemithombo ecatshulweyo (s)}
Umthombo (s)
Abramson A et al. 2019. Inkqubo yokuziqhelanisa nokuziqhelanisa nokuhanjiswa ngomlomo kweemacromolecules. Sayensi. 363. https://doi.org/10.1126/science.aau2277
