Uphononongo lubonisa ukuba ubunzima bomzimba womntu buchaphazela iziphumo zedosi ephantsi ye-aspirin ekuthinteleni iziganeko zentliziyo
Unyango lwe-aspirin yemihla ngemihla ngokobunzima bomzimba
Izifundo ezipapashwe kwi Lancet kubonise kulingo olungenamkhethe ukuba iziphumo zeyeza eliqhelekileyo le-aspirin ekuthinteleni iziganeko ze-cardiovascular zixhomekeke kakhulu kwisigulane. ubunzima1,2. Ke, iingenelo zokuthatha iyeza elifanayo azinakufaniswa nezigulane ezinomzimba ophezulu ubunzima. Uphononongo lwenziwe nabantu abanomzimba ubunzima phakathi kwe-50 kunye ne-69 yeekhilogram (kgs) (malunga ne-11,8000 yezigulane). Badle umthamo ophantsi we aspirin (75 ukuya kwi-100 mg) kwaye kwabonwa ukuba malunga neepesenti ze-23 inomngcipheko ophantsi wokuhlaselwa yintliziyo, ukubetha okanye enye into. isiganeko sentliziyo. Nangona kunjalo, izigulane ezine ubunzima ngaphezu kwe-70 kgs okanye nababekhaphukhaphu ngaphezu kwe-50 kgs babonakala bengafumani ncedo olufanayo lwedosi ephantsi ye-aspirin. Idosi ephantsi ye-aspirin yayiyingozi ngokwenene kwizigulane ezinobunzima obungaphezulu kwe-70 kgs kwaye zibulala izigulane ezingaphantsi kwe-50 kgs. Kwaye, ukunika aba baguli idosi ephezulu nangona kuluncedo kunokuba yingxaki njengoko idosi ephezulu elandelayo ye-aspirin yayiyidosi epheleleyo ye-325 mg eyaziwayo ngokubangela ukopha kakubi kwezinye izigulana. Nangona lo mngcipheko wokopha uye wahamba kwizigulane ezinobunzima obungaphezulu kwe-90kg. Nangona kunjalo, kusaza kuqwalaselwa malunga nokuba idosi ephezulu kangakanani na enokunikwa kuba abantu abaninzi bawela kudidi lwama-70 kg+ kwaye ke izibonelelo kunye nemingcipheko kufuneka zihlalutywe kunye.
Ngoko ke, ukubaluleka komzimba ubunzima Kubalulekile xa kuxoxwa ngokusebenza kwe-aspirin ekuthinteleni iziganeko zentliziyo kunye nomhlaza. Indlela 'yobukhulu obunye bulingana nayo yonke into' ifuna ukuchithwa kwaye isicwangciso esilungiselelwe ngakumbi kunye nesomntu ngamnye kufuneka samkelwe. Nangona idosi ecetyiswayo kanye nabantu abanomzimba ophezulu ubunzima (ngaphezu kwe-70 kgs) kusaza kuphandwa ngayo. Ababhali bacebisa ukuba i-aspirin ye-dose epheleleyo kufuneka isetyenziswe imihla ngemihla ngabantu abanobunzima obungaphezu kwe-69 kgs okanye ababhema kakhulu okanye bahlupheke kwimeko yesifo seswekile. Idosi ephezulu ingakhusela kwisigulana esisemngciphekweni ekunokwenzeka ukuba sibandezeleke kukumila kwamahlwili egazi okungafunwayo. Okubangel 'umdla kukuba, akukho mahluko phakathi kwamazinga e-stroke phakathi kwabesini efunyenweyo xa kuphela ubunzima bomzimba ibiyeyona ndlela yodwa. I-aspirin yedosi ephantsi ayisebenzi kwi-80 yepesenti yamadoda kwaye malunga ne-50 yepesenti yabasetyhini abanobunzima ubuncinane be-70 kgs ngaloo ndlela becela umngeni kwindlela eqhelekileyo yangoku yokumisela i-aspirin yedosi ephantsi kuzo zonke izigulane ezikwi-50 ukuya kwiqela le-69 yobudala.
Uphononongo lucebisa ukuba eyona nzuzo ilungileyo ye-aspirin yothintelo lwexesha elide lwezehlo zentliziyo kufuneka igxininise phantsi kwedosi kubantu abakhulu ngelixa i-overdose encinci. Enye yeempembelelo ezithe ngqo zolu phononongo kukunqanda ukusetyenziswa kwedosi ephezulu ye-aspirin (325 mg) kubantu abanobunzima obuphantsi (ngaphantsi kwama-70 kgs) njengoko kubonwa ukuba iidosi ezisezantsi zisebenza ngokwaneleyo thabatha naziphi na iingozi zedosi egqithisileyo. Kwaye idosi egqithisileyo inokubulala. Uphando olongezelelekileyo kufuneka lwenziwe ukuze kuqinisekiswe oku kufunyanisiweyo. Kodwa ngokucacileyo ezi ziphumo zinamandla okuchaphazela iinkqubo zempilo yoluntu ngokucenga ingxoxo ubunzima-edjusted idosi ye aspirin kukhathalelo lweklinikhi lwesiqhelo. Kwakhona, ukuthelekiswa kwe-aspirin kunye nezinye iidosi ze-antiplatelet okanye i-antithrombotic nazo zisekwe kubungakanani bomzimba kunye ubunzima. Kucacile ukuba idosi efanelekileyo ye-aspirin yokukhusela izifo zentliziyo / iziganeko zixhomekeke kubunzima bomzimba - oko kukuthi ubunzima bomzimba kunye nobude kune-BMI (I-Index Mass Mass). Olu phononongo lukwabeka phambili imbono yeyeza elichanekileyo, oko kukuthi, ukubonelela ngonyango lobuqu kwisigulana ngasinye.
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{Unokufunda iphepha lokuqala lophando ngokunqakraza ikhonkco le-DOI elinikwe ngezantsi kuluhlu lwemithombo ecatshulweyo (s)}
Umthombo (s)
1. URothwell PM et al. 2018. Iimpembelelo ze-aspirin kwimingcipheko yeziganeko ze-vascular kunye nomhlaza ngokwe-bodyweight kunye ne-dose: uhlalutyo lwedatha yesigulane ngasinye kwiimvavanyo ezingahleliwe. Lancet. 392(10145).
https://doi.org/10.1016/S0140-6736(18)31133-4
2. I-Theken KN kunye ne-Grosser T 2018. I-aspirin ye-Weight-adjusted for the cardiovascular prevention. Lancet.
https://doi.org/10.1016/S0140-6736(18)31307-2
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