Isitofu sokugonya esitsha, i-R21/Matrix-M senziwe isincomo yi-WHO ekuthinteleni isifo seengcongconi ebantwaneni.
Kwangoko ngo-2021, i-WHO yayicebise i-RTS,S/AS01 isitofu sokugonya isifo seengcongconi ukuthintela malariya ebantwaneni. Le yaba yeyokuqala malariya iyeza lokugonya eliza kucetyiswa.
I-R21/Matrix-M sisitofu sesibini semalariya esicetyiswa yi-WHO ekuthinteleni isifo seengcongconi ebantwaneni.
Ngenxa yokunqongophala konikezelo lwesitofu sokugonya i-RTS,S/AS01, isincomo sesibini malariya isitofu sokugonya i-R21/Matrix-M kulindeleke ukuba sivale umsantsa wonikezelo ukuhlangabezana nemfuno ephezulu.
Isindululo sesitofu sokugonya i-R21/Matrix-M sasisekelwe kwiziphumo ezincumisayo zesigaba sesi-III solingo lwezonyango olubandakanya abantwana abangama-4800 kwiindawo ezihlanu kumazwe amane ase-Afrika. Isitofu sokugonya sinenkangeleko yokhuseleko enyamezelekileyo kwaye sibonelela ngokusebenza okukwinqanaba eliphezulu ngokuchasene neklinikhi malariya.
Isitofu sokugonya esitsha sisitofu sokugonya esinexabiso eliphantsi kwaye kulindeleke ukuba sibe neempembelelo eziphezulu kwimpilo yoluntu ngokomthwalo wezifo kwi-Afrika ekwi-sub-Sahara.
Zombini izitofu ze-R21/Matrix-M kunye ne-RTS,S/AS01 zizitofu ezisekelwe kwi-antigen esekelwe kwi-circumsporozoite protein (CSP) kungoko ziyafana. Zombini zijolise kwi-plasmodium sporozoite. Nangona kunjalo, i-R21 ine-CSP-hepatitis B enye ye-antigen (HBsAg) yokudibanisa iprotheni. Oku kukhuthaza impendulo ephezulu ye-anti-CSP ye-antibody kunye nempendulo esezantsi ye-anti-HBsAg ye-antibody eyenza ibe sisizukulwana esilandelayo sesitofu sokugonya se-RTS, i-S.
I-R21/Matrix-M malariya isitofu sokugonya siphuhliswa yiYunivesithi yaseOxford. Yenziwa yiSerum Institute of India (SII) esele inomthamo wemveliso yeedosi ezili-100 lezigidi ngonyaka. I-SII iya kuphinda kabini umthamo wemveliso kule minyaka mibini izayo ukuhlangabezana nesidingo.
Isindululo se-WHO sivula indlela yokuthengwa nokuthengwa kwesitofu sokugonya abantwana abakwiindawo ezinengxaki.
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Imithombo:
- Ukukhutshwa kweendaba ze-WHO - WHO icebisa isitofu se-R21/Matrix-M sokuthintela isifo seengcongconi kwiingcebiso ezihlaziyiweyo ngogonyo. Ithunyelwe nge-2 Okthobha 2023. Iyafumaneka e https://www.who.int/news/item/02-10-2023-who-recommends-r21-matrix-m-vaccine-for-malaria-prevention-in-updated-advice-on-immunization Ifikeleleke nge-3 ka-Okthobha ngo-2023.
- Datoo, MS, okqhubekayo 2023. ISigaba sesi-III esiLawulwa ngokungaQonganga uVavanyo loVavanyo lweSitofu sokugonya seMalariya R21/Matrix-M™ kuBantwana base-Afrika. Ukuprintwa kwangaphambili kwi-SSRN. DOI: http://doi.org/10.2139/ssrn.4584076
- Laurens MB, 2020. isitofu sokugonya i-RTS,S/AS01 (Mosquirix™): isishwankathelo. I-Hum Vaccin Immunother. 2020; 16(3): 480–489.Ipapashwe kwi-intanethi 2019 Oct 22. DOI: https://doi.org/10.1080/21645515.2019.1669415
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