Kuphononongo lwamva nje lwe-vivo kwi-Zebrafish, abaphandi baye bakhuthaza ngempumelelo ukuvuselelwa kwediski kwidiski eyonakeleyo ngokuvula i-endogenous Ccn2a-FGFR1-SHH yokubonisa i-cascade. Oku kubonisa ukuba Ccn2a protein ingasetyenziswa ekukhuthazeni ukuvuselelwa kwe-IVD kunyango lwe-backpain.
umva intlungu yingxaki eqhelekileyo yempilo. Sesinye sezona zizathu zixhaphakileyo zokuba abantu bafune ukudibana noogqirha. Le meko ibangelwa ikakhulu ngenxa yokuncipha kwe-disc intervertebral disc (IVD) eyenzeka ngokwemvelo ngenxa yokugqoka kunye nokukrazula okanye ukuguga. I-analgesics kunye ne-anti-inflammatories kunye ne-physiotherapy zisetyenziselwa ukunyanga iimpawu. Kwiimeko ezinzima, ukutshintshwa kwediski okanye utyando lwe-disc fusion lunokusetyenziswa. Ngaloo ndlela, akukho nyango. Akukho nyango lwaziwayo okanye inkqubo luncedo ekubuyiseleni i-disc homeostasis. Isisombululo sengxaki silele ekufumaneni indlela yokucinezela i-disc degeneration kunye / okanye ukubangela ukuvuselelwa kwediski.
Kuphononongo lwe-in-vivo kwiZebrafish, echazwe kwi-6th NgoJanuwari 2023, abaphandi bafumanisa ukuba inethiwekhi yonxibelelwano lweSelula 2a (Ccn2a), a protein efihliweyo ngamaseli e-disc intervertebral disc ibangela ukuvuselelwa kwediski kwiidiski ezindala eziguquguqukayo ngokukhuthaza ukwanda kweeseli kunye nokusinda kweeseli ngokumodareyitha kwe-FGFR1-SHH (i-Fibroblast ukukhula kwe-receptor-Sonic Hedgehog) indlela.
Kuyabonakala ukuba, oku kukuqala ngqa ukuba ukuvuselelwa kwediski kwidiski eyonakeleyo kuye kwanyanzelwa kwi-vivo ngokuvula i-endogenous signing cascade.
Olu phuhliso lunokuba linyathelo lokuyila isicwangciso senoveli ukucinezela i-disc degeneration okanye ukukhuthaza ukuvuselelwa kwediski kwiidiski zomntu.
***
Iingxelo:
URayrikar AY, okqhubekayo 2023. Ukubonakaliswa kwe-Ccn2a-FGFR1-SHH kuyimfuneko kwi-intervertebral disc homeostasis kunye nokuvuselelwa kwi-zebrafish yabantu abadala. Uphuhliso. Umqulu 150, ushicilelo 1. Ipapashwe 06 January 2023. DOI: https://doi.org/10.1242/dev.201036
***
