Abaphandi baye benza i-2-dimensional mineral nanoparticles ukuhambisa unyango emzimbeni wokuvuselelwa kwe-cartilage.
Osteoarthritis sisifo esiwohlokayo esichaphazela abantu abazizigidi ezingama-630 kwihlabathi liphela nto leyo ephantse ibe yi-15 ekhulwini labantu bonke iplanethi. Kwi-osteoarthritis, i-cartilage emathanjeni ethu iqala ukuphuka kwaye oku kunokonakalisa ithambo elingaphantsi elibangela intlungu kunye nokuqina, ngakumbi emadolweni, e-hip kunye namalungu esithupha. Iziganeko zale meko ziyanda njengoko sikhula. Unyango lwe-osteoarthritis lubandakanya amayeza, iphysiotherapy, unyango lwasemsebenzini olujoliswe ikakhulu ekudambiseni iimpawu zentlungu. Ukunyanga le meko ngokupheleleyo, izicubu ezidibeneyo ezonakalisiweyo kufuneka zilungiswe. Olu lungiso lunzima kwaye lucelomngeni njengoko izicubu ze-cartilage kwithambo kunzima ukuvuselela. Njengoko abantu behlabathi bekhula, unyango olutsha olusebenzayo lwe-osteoarthritis luyafuneka ngoko nangoko.
Imiba yokukhula protein
Unyango olunokwenzeka lwe-osteoarthritis lubandakanya uyilo kunye nokuhanjiswa protein amayeza okt protein yenziwe elabhoratri ukuze isetyenziswe kunyango. protein amayeza anempembelelo enkulu kwizifo ezininzi kumashumi eminyaka akutshanje. Enye iklasi enjalo protein ibizwa ngokuba yimiba yokukhula enyibilikayo eyimfihlo protein. Umzimba wethu uyakwazi ukuziphilisa kwaye le nkqubo inokuphuculwa ngokusetyenziswa kokwenziwa kwezinto ezikhulayo zokuphucula iinkqubo ezibandakanyekayo ekuziphiliseni. Nangona kunjalo, uninzi lwezinto ezaziwayo zokukhula ziqhekeka ngokukhawuleza kwaye ke idosi ephezulu kakhulu iyafuneka ukufezekisa isiphumo sonyango. Uphononongo lubonise iziphumo ezibi zedosi ephezulu njengokudumba kunye nokwakheka kwezicubu ezingalawulwayo. Ukusetyenziswa kwemiba yokukhula kukwanqongophele kakhulu ngenxa yokungabikho kweenkqubo zokuhanjiswa kweenkonzo ezisebenzayo okanye abathwali bebhayiloji. Izinto zokukhula kunye neenkqubo ezisebenzayo zokuhanjiswa kwe-biomaterial zibalulekile kunyango lokuhlaziya olubandakanya ukulungiswa kwezicubu kunye nokuvuselelwa.
Unyango olutsha lwe-osteoarthritis esekwe kwi-nanosilicates
Abaphandi kwiYunivesithi yaseTexas A & M, eU.SA bajolise ekuphuhliseni unyango olunoveli lokuvuselelwa kwe-cartilage ngokuyila i-nanoparticles yamaminerali amabini-dimensional (2D) angasetyenziselwa ukuhambisa izinto zokukhula. Ezi nanoparticles (okanye i-nanosilicates) zineempawu ezimbini eziphambili - indawo ephezulu kunye nentlawulo ephindwe kabini - evumela ukuba kube lula ukudibanisa izinto zokukhula. I-Nanosilicates ibonisa ukusebenza okuphezulu kokubopha kwizinto zokukhula ngaphandle kokuchaphazela iiprotheni Ukuhambelana kwe-3D okanye umsebenzi wayo webhayoloji. Bavumela unikezelo oluzinzileyo olude (ngaphezulu kweentsuku ezingama-30) zezinto zokukhula kwiiseli ze-mesenchymal stem ezithi ke zisetyenziswe ekuvuseleleni i-cartilage ngokukhuthaza ukwahlula okuphuculweyo kweeseli ze-stem ukuya kwi-cartilage. Ukwahlula okuphuculweyo kuqinisekisa umsebenzi ophezulu wokukhutshwa protein kunye nokuba kugxininiso oluphantsi ka-10 xa kuthelekiswa nonyango lwangoku olusebenzisa idosi ephezulu kakhulu.
Olu phononongo lupapashwe kwi Izixhobo eziSetyenzisiweyo ze-ACS kunye neNdlela ibonisa inkqubo ye-nanoengineered - iqonga elisekelwe kwi-nanoclay apho i-nanosilicates ingasetyenziselwa njengesithuthi sokuhambisa ukwenzela ukuba ukuhanjiswa okuqhubekayo protein amayeza okunyanga i-osteoarthritis. Inkqubo enjalo yokuhanjiswa kwe-biomaterial inokuqinisekisa unyango olusebenzayo lwe-osteoarthritis ngokunciphisa iindleko zizonke kunye nokunciphisa imiphumo emibi. Eli qonga litsha lonikezelo linokunyusa izicwangciso zangoku zokuvuselela amathambo kunye nokwenza impembelelo kwiyeza lokuvuselela.
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Umthombo (s)
UCross LM et al 2019. Ukuhanjiswa okuZinzileyo kunye nexesha elide loku protein Unyango oluvela kwi-Nanosilicates ene-Two-Dimensional. IiMathiriyeli eziFakelwe i-ACS kunye neNdibaniselwano. 11. https://doi.org/10.1021/acsami.8b17733
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Amagqabantshintshi zivaliwe.