Iloprost, i-analog yeprostacyclin yokwenziwa esetyenziswa njenge-vasodilator ukuya baphathe I-pulmonary arterial hypertension (PAH), ivunyiwe yi-US ukutya kunye noLawulo lweDrugs kunyango lweqabaka eqatha. Oku kuqala kuvunywe amayeza e-USA ukunyanga iqabaka eqatha kubantu abadala ukunciphisa umngcipheko wokunqunyulwa.
I-Frostbite yimeko enzima efuna ngokukhawuleza zonyango ingqalelo. Ibangelwa ngenxa yokuvezwa kubushushu obubandayo ixesha elide ukuvumela iikristale zomkhenkce ukuba zenze izicubu. Abantu abasebenza ngaphandle kwiindawo ezibandayo ezifana nabantu bokhuseleko, abasebenzi befektri, abakhweli beentaba okanye abakhweli njalo njalo badla ngokuchatshazelwa yiqabaka. Ukunqunyulwa kweminwe neenzwane ngenxa yeqabaka kuyinto eqhelekileyo kwimimandla enjalo nangona kukho inkqubela phambili impilo iinkonzo zokhathalelo.
Iloprost yi-analog yeprostacyclin yokwenziwa. Ibuyisela i-vasoconstriction kwaye inqanda ukusebenza kweplatelet, isebenza njenge-vasodilator, ivula imithwalo yegazi kwaye inqande ukuchithwa kwegazi. Yavunywa okokuqala kwi-2004 yonyango lwe-pulmonary arterial hypertension (PAH).
Iloprost kunye ne-thrombolytics ziluncedo ekuphatheni i-frostbite. ECanada, izigulane kunye neqabaka enzima ebandakanya ukukhenkceza kwesikhumba kunye nezicubu ezingaphantsi kunye nokuyeka ukuhamba kwegazi kuye kwaphathwa ngempumelelo nge-iloprost. Iyeza elidala ngoku livunyiwe yi-US Food and Drug Administration (FDA) kunyango lwe-frostbite enzima.
The FDA inike imvume kwi-Eicos Sciences Inc. ukuba yenze iloprost yonyango lweqabaka emandla ngegama lebrendi "Aurlumyn".
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Iingxelo:
- FDA Ivuma iyeza lokuqala lokuNyanga iFrostbite. Iposwe nge-14 kaFebruwari 2024. Iyafumaneka e https://www.fda.gov/news-events/press-announcements/fda-approves-first-medication-treat-severe-frostbite/
- Regli, IB, Oberhammer, R., Zafren, K. et al. Unyango lwe-Frostbite: ukuphononongwa okucwangcisiweyo kunye nohlalutyo lwe-meta. Scand J Trauma Resusc Emerg Med 31, 96 (2023). https://doi.org/10.1186/s13049-023-01160-3
- I-Poole A. kunye ne-Gauthier J. 2016. Unyango lwe-frostbite enzima kunye ne-iloprost enyakatho yeCanada. CMAJ Disemba 06, 2016 188 (17-18) 1255-1258; DOI: https://doi.org/10.1503/cmaj.151252
- Gruber, E., Oberhammer, R., Brugger, H. et al. Ixesha elide lokungcwatywa kwe-avalanche enzima malunga ne-23 h kunye ne-hypothermia enzima kunye ne-frostbite enzima ngokuchacha kakuhle: ingxelo yecala. Scand J Trauma Resusc Emerg Med 32, 11 (2024). https://doi.org/10.1186/s13049-024-01184-3
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