Kulo nyaka Nobel Ibhaso kwiPhysiology okanye iyeza Unyaka ka-2023 unikezelwe ngokudibeneyo kuKatalin Karikó kunye noDrew Weissman “ngokufumanisa kwabo malunga nohlengahlengiso lwesiseko se-nucleoside esenze ukuba kuphuhliswe ugonyo olusebenzayo lwe-mRNA ngokuchasene ne-COVID-19”.
Bobabini uKatalin Karikó kunye noDrew Weissman banxulumana neDyunivesithi yasePennsylvania. Igalelo labo ekusetyenzisweni kwetekhnoloji ye-mRNA kugonyo kunye neenjongo zonyango zitshintshe ngokusisiseko ukuqonda kwendlela i-mRNA enxibelelana ngayo ne-immune system kwaye idlale indima ebalulekileyo ekuphuhliseni. lokugonya ngokuchasene nobhubhani we-COVID-19 ngesantya esingazange sabonwa ngaphambili ukuhlangabezana nongxamiseko.
Isiganeko esiphambili yayikukuqwalasela kwabo ukuba iiseli ze-dendritic ziyayibona i-in vitro ibhalwe i-mRNA njengento yangaphandle ngelixa i-mRNA evela kwiiseli ezincancisayo ayizange ibangele ukusabela komzimba. Baye baphanda ukuba ukungabikho kweziseko ezitshintshiweyo kwi-in vitro ezibhalwe kwi-RNA kunokubangelwa ukusabela okungafunwayo kwaye bafumanisa ukuba impendulo yokuvuvukala yapheliswa xa ukuguqulwa kwesiseko kufakwe kwi-mRNA. Oku kufunyanisiweyo kususe umqobo ophambili ekusebenziseni itekhnoloji ye-mRNA kuphuhliso lwesitofu kunye nonyango kwaye yapapashwa ngo-2005.
Kwiminyaka elishumi elinesihlanu emva koko, imeko engazange ibonwe ngaphambili eboniswe ngubhubhani we-COVID-19 ikhokelele kulingo olukhawulezayo lwezonyango kunye ne-EUA yogonyo olusebenzayo lwe-mRNA ngokuchasene ne-COVID-19. Isitofu sokugonya se-mRNA ngokuchasene ne-COVID-19 yaba linyathelo elibalulekileyo kwisayensi kunye nokutshintsha komdlalo iyeza.
Ngoku, itekhnoloji ye-mRNA itekhnoloji eqinisekisiweyo yophuhliso lwe lokugonyas kunye nonyango.
umthombo:
NobelPrize.org. Ukukhutshwa kweendaba - I Nobel IBhaso kwiPhysiology okanye kwiMedicine 2023. Ithunyelwe nge-2 Okthobha 2023. Ifumaneka apha https://www.nobelprize.org/prizes/medicine/2023/press-release/
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