Itekhnoloji ye-RNA ibonakalise ukubaluleka kwayo kutshanje kuphuhliso lwezitofu ze-mRNA i-BNT162b2 (ye-Pfizer/BioNTech) kunye ne-mRNA-1273 (yeModerna) ngokuchasene ne-COVID-19. Ngokusekwe ekuthobeni ikhowudi ye-RNA kwimodeli yezilwanyana, izazinzulu zaseFransi ziye zabika isicwangciso esinamandla kunye nobungqina bengcamango yonyango lweCharcot-Marie-Tooth. isifo, esona sifo sixhaphakileyo sofuzo semithambo-luvo esibangela ukukhubazeka okuqhubekayo kwemilenze nezandla.
Ngowe-1990, abaphandi babonisa okokuqala ukuba inaliti ethe ngqo ye mRNA kwisihlunu sempuku kukhokelele ekubonakalisweni kweprotheyini enekhowudi kwiiseli zezihlunu. Oku kwavula ithuba lophuhliso lwemfuza esekwe zokugonya kunye nonyango.
Imeko engakhange iboniswe ngubhubhani we-COVID-19, ikhokelele kuphuhliso oluyimpumelelo kunye nogunyaziso losetyenziso olungxamisekileyo (EUA) lwe-mRNA-based. zokugonya BNT162b2 (ye Pfizer/BioNTech) kunye ne-mRNA-1273 (ye Kule mihla) ngokuchasene ne-COVID-19. Ezi zimbini zokugonya Ngokusekwe kubuchwephesha be-RNA badlale indima ebalulekileyo ekukhuseleni abantu kwiimpawu ezinzima ze-COVID-19.
Impumelelo yetekhnoloji ye-RNA esekwe kwi-COVID-19 zokugonya yathathwa njengesiganeko esibalulekileyo kwezenzululwazi kunye namayeza njengoko ibonakalise ukufaneleka kobuchwepheshe obuphezulu bezonyango obulandelwa luluntu lwezenzululwazi kunye neshishini lamayeza malunga namashumi amathathu eminyaka. Inike ugxininiso olufuneka kakhulu ekuphononongeni unyango olusekwe kwitekhnoloji ye-RNA.
Isifo sikaCharcot-Marie Tooth sesona sixhaphakileyo sofuzo lwemithambo-luvo isifo. Imithambo yeperipheral iyachaphazeleka nto leyo ekhokelela ekukhubazekeni okuqhubekayo kwemilenze nezandla. Esi sifo sibangelwa ngenxa yokugqithiswa kweprotheyini ethile ebizwa ngokuba yi-PMP22. Alukho unyango oluchasene nesi sifo ukuza kuthi ga ngoku.
Izazinzulu kwi-CNRS, INSERM, i-AP-HP kunye ne-Paris-Saclay kunye ne-Paris kwiiyunivesithi zaseFransi kutshanje zichaze uphuhliso lonyango olusekelwe ekuthotyweni nasekunciphiseni ikhowudi ye-RNA yeprotheni ye-PMP22. Kule nto, basebenzisa enye i-siRNA (i-RNA encinci ephazamisayo) i-molecule ephazamisana ne- RNA ikhowudi yeprotheni ye-PMP22.
Abaphandi bafumanise ukuba inaliti ye-siRNA (i-RNA encinci ephazamisayo) kwimodeli yeempuku zesifo yanciphisa inqanaba leprotheyini ye-PMP22 ukuya kwindawo eqhelekileyo kunye nokubuyiselwa kokuhamba kunye namandla emisipha. Izifundo ze-Histological zibonise ukuvuselelwa kunye nokubuyiselwa komsebenzi we-myelin sheaths. Iziphumo ezilungileyo zahlala iiveki ezintathu, kwaye inaliti ehlaziyiweyo ye-siRNA yakhokelela ekubuyiseleni ukusebenza ngokupheleleyo.
le isifundo ibalulekile kuba icebisa isicwangciso esinamandla sonyango lwe-peripheral neuropathies. Ibonelela nge ubungqina bengqiqo iyeza elitsha elichanekileyo elisekwe kusetyenziso lwetekhnoloji ye-RNA ukulungisa ukubonakaliswa kwemfuza okugqithisileyo ngokusetyenziswa kwe-RNA ephazamisayo.
Nangona kunjalo, olona nyango lwesigulana luseyinde indlela de izigaba ezilandelelanayo zolingo lwezonyango zibonelele ngokhuseleko olwanelisayo kunye neziphumo ezisebenzayo kubalawuli.
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Imithombo:
- Prasad U., 2020. Isitofu sokugonya se-COVID-19 mRNA: Imbali yeNzululwazi kunye noTshintsho loMdlalo kuNyango. Inzululwazi yaseYurophu. Ithunyelwe nge-29 kuDisemba 2020. Iyafumaneka apha https://www.scientificeuropean.co.uk/covid-19/covid-19-mrna-vaccine-a-milestone-in-science-and-a-game-changer-in-medicine/
- Ukukhutshwa kwe-Press Release - I-Inserm Press Room - Isifo seCharcot-Marie Tooth: I-100% ye-RNA yaseFransi esekelwe kwi-repeutic innovation. Ikhonkco: https://presse.inserm.fr/en/charcot-marie-tooth-disease-a-100-french-rna-based-therapeutic-innovation/42356/
- Boutary, S., Caillaud, M., El Madani, M. et al. I-Squalenoyl siRNA PMP22 nanoparticles iyasebenza ekuphatheni imodeli yemouse yeCharcot-Marie-Tooth uhlobo lwesifo 1 A. Commun Biol 4, 317 (2021). https://doi.org/10.1038/s42003-021-01839-2
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