Intsholongwane yemonkeypox (MPXV), ebizwa njalo ngenxa yokufunyanwa kwayo okokuqala kwiinkawu ezigcinwe kwindawo yophando eDenmark, inxulumene ngokusondeleyo nentsholongwane ye-variola ebangela i-smallpox. Ijongene nesifo semonkeypox (impoksi) esithe savela ngokuthe ngcembe e-Afrika emva kokupheliswa kwengqakaqha kunye nokupheliswa kogonyo lwengqakaqha. Inamacandelwana amabini: iclade I kunye neclade II. I-clade II inamacandelwana amabini. Ubhubhani ka-2022 ubalelwa kwi-subclade IIb. Ukuqhambuka ngokukhawuleza kwe-Oktobha 2023 kwingingqi yaseKamituga yase-DR Congo kwafunyaniswa ukuba idluliselwe ngoqhagamshelwano lwezesondo kwaye yabangelwa umgca we-MPXV Clade Ib ocacileyo wokudluliselwa komntu kumntu. Kubekho ukunyuka kwamatyala e-pox e-DR Congo nakwamanye amazwe amaninzi e-Afrika. Amazwe amaninzi aseYurophu nawo anike ingxelo ngokuqhubekayo ukonyuka kwenani losulelo lwemonkeypox ukusukela ngoMeyi ka-2022.
Ngenxa yokuvela kweentlobo ezitsha ezinosulelo oluphezulu kunye nentsholongwane, i-epidemiology eguqukayo ngokukhawuleza kumazwe onke kulo mmandla, kunye nobukhali ebantwaneni nakubantu abakhubazekileyo, i-IHR (iMimiselo yezeMpilo yeHlabathi, ka-2005) iKomiti kaNgxamiseko, kwintlanganiso yayo yokuqala ebibanjwe ngo. I-14 Agasti 2024, ithathelwe ingqalelo ukuqhambuka kweMpox njengesiganeko esingaqhelekanga esenza ingozi yempilo yoluntu kwamanye amazwe ngokusasazeka kwezifo kumazwe ngamazwe. Isiganeko esinjalo sifuna impendulo elungelelanisiweyo yamazwe ngamazwe. IKomiti icebise ukuba ukuqhambuka kwangoku kwe-mpox kuhlangabezana nemilinganiselo yonxunguphalo lwempilo yoluntu lwenkxalabo yamazwe ngamazwe (PHEIC).
Ngokufanelekileyo, ukuqhambuka kwe-mpox e-DR Congo nakwamanye amazwe ase-Afrika kwabhengezwa njengengxakeko yezempilo yoluntu kwinkxalabo yamazwe ngamazwe (PHEIC) ngomhla we-14 Agasti 2024. Ingxelo yentlanganiso yokuqala ye-Mpox IHR Emergency Committee 2024 sele ikhutshwe yi-WHO.
Unyango lweMpox
Ngenxa yokuba intsholongwane yemonkeypox (MPXV) isondelelene nengqakaqha, unyango lwengqakaqha lunokuba luncedo ekunyangeni iimeko zepox. Ngoko ke, ichiza le-antiviral i-tecovirimat (okanye i-TPOXX) elaphuhliswa kuqala kwaye lamkelwa ukunyanga i-smallpox ligunyaziswe eYurophu nase-United Kingdom kunyango lwe-mpox. I-Arhente yaMayeza yaseYurophu ivume i-tecovirimat yonyango lwe-mpox ngoJanuwari 2022 phantsi kweemeko ezikhethekileyo.
Ubungqina kumxholo we-mpox bulinganiselwe kakhulu ngoko ke ukusetyenziswa kwe-tecovirimat kuhamba kunye nokubhaliswa kulingo lwezonyango. E-USA, okwangoku iyafumaneka kunyango lwe-mpox njengenxalenye yolingo lwezonyango.
Ukhuseleko kunye nokusebenza ngempumelelo kwe-Tecovirimat njengonyango lwempoksi kusaza kumiselwa.
Ulingo lwezonyango lweTecovirimat (TPOXX) loNyango lweMpox
Ulingo olungenamkhethe, olulawulwa yi-placebo lwaphehlelelwa ngo-Okthobha ka-2022 ukuhlola ukhuseleko kunye nokusebenza kwechiza le-antiviral i-tecovirimat kubantu abanemonkeypox e-DR Congo elilizwe eline-mpox-endemic. Iimeko ezingama-597 eziqinisekisiweyo ze-mpox zabhaliswa kwaye zaphathwa ngokungenamkhethe nge-tecovirimat okanye i-placebo esibhedlele kwaye zajongwa ukusonjululwa kweempawu ze-mpox.
Isiphumo sokuqala sophononongo sicebisa ukuba ichiza le-antiviral i-tecovirimat lalikhuselekile kubathathi-nxaxheba bophononongo. Ayizange ibangele nayiphi na imiphumo ebalulekileyo emibi. Nangona kunjalo, ayizange isebenze ekunciphiseni ixesha lezilonda ze-mpox nge-clade I mpox. Nangona kunjalo, ukufa phakathi kwabathathi-nxaxheba bekusezantsi kunokokusweleka kwepox kukonke e-DRC. Ukufa kuncitshisiwe kwaye izilonda zisonjululwe ngokukhawuleza kubathathi-nxaxheba bolingo kungakhathaliseki ukuba bafumana i-tecovirimat okanye i-placebo. Oku kuphakamisa isiphumo esingcono sempilo xa ulaliswe esibhedlele kwaye unikezela ngokhathalelo oluyimfuneko.
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Iingxelo:
- Ukukhutshwa kweendaba ze-WHO - Intlanganiso yokuqala yeMimiselo yezeMpilo yeZizwe ngezizwe (2005) iKomiti eNgxamisekileyo malunga nokunyuka kwempox 2024. Ithunyelwe ngo-19 Agasti 2024. Ifumaneka kwi- https://www.who.int/news/item/19-08-2024-first-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-upsurge-of-mpox-2024
- I-WHO. Ukukhutshwa kweendaba – iMpox Q&A. Ithunyelwe nge-17 Agasti 2024. Iyafumaneka e https://www.who.int/news-room/questions-and-answers/item/mpox
- I-CDC. I-Tecovirimat (TPOXX) yoNyango lwe-Mpox. Ifumaneka e https://www.cdc.gov/poxvirus/mpox/clinicians/tecovirimat-ea-ind.html
- I-NIH 2024. Ukukhutshwa kweendaba - I-antiviral tecovirimat ikhuselekile kodwa ayizange iphucule isisombululo se-clade I mpox eDemocratic Republic of the Congo. Ithunyelwe nge-15 Agasti 2024. Iyafumaneka e https://www.nih.gov/news-events/news-releases/antiviral-tecovirimat-safe-did-not-improve-clade-i-mpox-resolution-democratic-republic-congo
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Amanqaku afanelekileyo:
Uqhambuko lweMonkeypox (Mpox) lubhengeze iNgxamiseko yeMpilo yoLuntu yeNgxaki yeHlabathi (14 Agasti 2024)
Izitofu zokugonya i-Monkeypox (Mpox): I-WHO iqalisa inkqubo ye-EUL (10 Agasti 2024)
Uxinzelelo lweNkawu lweNkawu (MPXV) Lusasazeke ngokuNxibelelana ngokwesondo (20 April 2024)
Intsholongwane yemonkeypox (MPXV) ezahlukeneyo ezinikwe amagama amatsha (12 Agasti 2022)
Ngaba iMonkeypox iya kuhamba ngendlela yeCorona? (23 ngoJuni 2022)
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