Izifo ze-Fibrotic zaziwa ngokuchaphazela amalungu amaninzi abalulekileyo emzimbeni kwaye zingoyena nobangela wokufa kunye nokugula. Kubekho impumelelo encinci kunyango lwezi zifo ukuza kuthi ga ngoku. I-ILB®, iMolekyuli ePhantsi ubunzima I-Dextran Sulfate (LMW-DS) ibonise iziphumo ezithembisayo kwi-pre-klinikhi ityala. Kufunyenwe ukusombulula ukuvuvukala kunye nokwenza kusebenze ukulungiswa kwe-matrix kwimodeli ye-rodent kunye nezifo zabantu. Ngokucacileyo, i-ILB® ibonakala inamandla okunyanga izifo ze-fibrotic. Eyona nto inomdla kukuba kunokwenzeka unyango lwe-anti-fibrotic kwi-glaucoma. Kodwa ngaphambi kokuba ivunywe, kufuneka iqhubele phambili ngakumbi klinikhi izilingo.
Xa ukuvuvukala kubangelwa ngenxa yezinto ezifana nezifo, i-autoimmunity, i-toxins, i-radiation, ukulimala komatshini njl. Kuhlala ixesha elide (ukuvutha okungapheliyo), ukuguqulwa kwezicubu kunye neenkqubo zokulungisa zenzeka ngaxeshanye. Inkqubo yokulungisa inezigaba ezimbini - ukuvuselelwa (iiseli ezintsha zohlobo olufanayo zithatha indawo yeeseli ezilimele) kunye i-fibrosis (izicubu ezixhumeneyo zithatha indawo yeeseli eziqhelekileyo). Xa ingalawulwa, inkqubo yokulungisa ikhokelela ekufakweni kwe-matrix ye-extracellular (ECM) ekhokelela ekugqibeleni ekutshintshweni kwezicubu eziqhelekileyo kunye nezicubu ezingapheliyo.
I-fibrosis engaqhelekanga ngenxa yesifo esingapheliyo kwaye singasonjululwanga ukukrala Ixhaphakile kwaye iyi-pathology engundoqo emva kwenani elikhulu lezifo ezichaphazela amalungu abalulekileyo afana nemiphunga, isibindi, intliziyo, i-pancreas, iliso, ingqondo, amathumbu, ulusu njl. Ezi zifo zingunobangela omkhulu wokufa kunye nokugula kwihlabathi jikelele. Ngokutsho koqikelelo malunga nama-45% abo bonke abantu abaswelekayo babalelwa kwi-fibrosis. Unyango lwezifo ze-fibrotic aluqhelekanga ukuphumelela ngenxa yokufuna iarhente efanelekileyo yonyango enokusombulula ukudumba, ukubamba i-fibrosis engaqhelekanga, kwaye kusebenze ukuvuselelwa kwesiqhelo. izicubu ngaloo ndlela ibuyisela i-homoeostasis yezicubu eziqhelekileyo ngaphandle kwemiphumo emibi. Nayiphi na i-ejenti yonyango enjalo iya kuba nentsingiselo enkulu kuluntu kunye nezoqoqosho.
Kuphononongo lwangaphambili, i-ILB® sele ibonisiwe ukuba ikhuselekile ebantwini. Kolu phononongo, abaphandi baphanda iimolekyuli eziphantsi ubunzima i-dextran sulfates (LMW-DS) kwimifuziselo yeempuku kunye nezifo zabantu. Kwafunyaniswa ukuba i-ILB®, i-Molecular Low ubunzima I-Dextran Sulfate (LMW-DS) –
- imodareyitha ukudumba kunye ukupholisa inxeba iimpendulo kwiiseli zoluntu ezikhulisiweyo,
- imodareyitha ukubonakaliswa kofuzo oluvuthayo kunye ne-fibrogenic kwiiseli zomntu ezikhulisiweyo, kunye
- yehlisa amanqanaba e-fibronectin kwiiseli ze-trabecular meshwork yabantu ezikhulisiwe kwaye isombulule ukukrala okukrala kwimodeli ye-glaucoma.
Ngoko ke, iziphumo zolu vavanyo lwangaphambiliklinikhi Ulingo lucebisa ukuba i-LMW-DS inokusombulula ukukrala kokuvuvukala kwaye ikhuthaze ukuvuselelwa kwezicubu ezisebenzayo. Obu bungqina bengqiqo benza i-ILB® ibe ngumgqatswa onokubakho kunyango lwezifo ezininzi ze-fibrotic eziquka iglaucoma.
***
Umthombo (s):
- Hill, LJ, Botfield, HF, Begum, G. et al. 2021. I-ILB® iSombulula uKukrala okuKhulekayo kwaye ikhuthaza ukulungiswa kweTissue eSebenzayo. Ipapashwe: 07 January 2021. npj Regenerative Medicine umthamo 6, Inombolo yenqaku: 3. DOI: https://doi.org/10.1038/s41536-020-00110-2
- I-Wynn TA 2006. Iinkqubo zeeseli kunye neemolekyuli ze-fibrosis. I-Journal of Pathology Volume 214, Issue 2. Yapapashwa okokuqala: 27 December 2007. DOI: https://doi.org/10.1002/path.2277
***
