Izixhobo ezinxitywayo ziye zaxhaphaka kwaye ziya zisanda. Ezi zixhobo zihlala zijongana ne-biomaterials kunye ne-electronics. Ezinye izixhobo ezinxitywayo ze-electro-magnetic zisebenza njengezivuni zamandla ngoomatshini ukunika amandla. kungoku nje, akukho "ujongano oluthe ngqo lwe-electro-genetic" lukhoyo. Ke ngoko, izixhobo ezinxitywayo azikwazi ukucwangcisa ngokuthe ngqo unyango olusekwe kwimfuza. Abaphandi baye baphuhlisa ujongano lokuqala oluthe ngqo lwe-electro-genetic eyenza intetho ye-transgene kwiiseli zomntu. Ebizwa ngokuba yi-DART (i-DC ye-teknoloji yolawulo olusebenzayo ngoku), isebenzisa unikezelo lwe-DC ukuvelisa iintlobo ze-oksijini ezisebenzayo ezisebenza kubakhuthazi bokwenziwa ukuze babonise. Kuhlobo loku-1 lwemodeli yempuku yeswekile, isixhobo sivuselele iiseli zomntu ezifakwe ngaphantsi kobunjineli ukukhulula i-insulin ebuyisele isiqhelo. igazi inqanaba leswekile.
Izixhobo zombane ezinxitywayo ezifana ne-smartwatches, iitracker zokuqina komzimba, Iintloko zeVR, ubucwebe obukrelekrele, iiglasi ezisebenza kwiwebhu, ii-headsets zebluetooth kunye nezixhobo ezininzi ezinxulumene nempilo zixhaphakile kule mihla kwaye ziya zisanda ngakumbi kwimpilo. Ngokuqhelekileyo izixhobo ezingabonakaliyo, ezinxulumene nempilo zijongana ne-biomaterials (kuquka i-enzymes) kunye ne-electronics kwaye zisetyenziselwa ukubeka esweni ukuhamba, iimpawu ezibalulekileyo kunye ne-biomarkers kwi-biofluids (ukubila, amathe, i-interstitial fluid kunye neenyembezi). Ezinye izixhobo ezinokunxitywa izixhobo ze-electro-magnetic zikwasebenza njengezivuni zamandla ngoomatshini ukunika amandla.
Ukunxibelelana izixhobo ezinxibekayo idlala indima ephambili ekuqokeleleni idatha yezempilo yabantu enokuthi ibe luncedo ekuboneleleni ngokhathalelo lwempilo lomntu siqu kuquka nonyango olusekelwe kwimfuza. Uhlobo lwe-1 sikashukela Yenye imeko apho isixhobo sokubeka iliso esinxitywayo sinokuvuselela kwaye silawule ukubonakaliswa kwe-insulin kwiiseli zomntu ezenziwe ngobunjineli obungaphantsi kwedermally ukukhulula i-insulin kunye nokubuyisela izinga leshukela legazi eliqhelekileyo. Izixhobo ziya kufuna i-electro-genetic interface ukulawula ukubonakaliswa kofuzo. Kodwa ngenxa yokungafumaneki kwalo naluphi na unxibelelwano olusebenzayo, umhlaba we-elektroniki kunye nofuzo uhlala ungahambelani kakhulu, kwaye izinto zokunxiba azikaphuhlisi ukubonelela. amayeza asekelwe kwimfuza.
Abaphandi base-ETH Zurich, eBasel, eSwitzerland baye baphumelela kutshanje ekuphuhliseni ujongano olunjalo olwenza ukuba isixhobo sombane sinxibelelane nehlabathi lemfuza ngokusebenzisa i-DC ephantsi yangoku. Ebizwa ngokuba yi-DART (ithekhinoloji yolawulo ethe ngqo ekhoyo ngoku), oku kuvelisa amanqanaba angeyotyhefu iintlobo zeoksijini esebenzayo ukubuyisela umva kakuhle abakhuthazi bokwenziwa. Kwimodeli yempuku, ukusetyenziswa kwayo kukhuthaze ngempumelelo iiseli zomntu ezifakwe phantsi kwesikhumba ukukhulula i-insulin kunye nokubuyisela inqanaba leswekile yegazi.
Okwangoku, i-DART ibonakala ithembisa, kodwa iye yadlula kubunzima bolingo lwezonyango kwaye yangqina ukufaneleka kwayo ngokokhuseleko nokusebenza kwayo. Kwixesha elizayo, izixhobo zombane ezinxitywayo ezine-DART zinokuba kwindawo yokucwangcisa ngqo ungenelelo lwemetabolism.
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Iingxelo:
- UKim J., okqhubekayo., 2018. I-Bioelectronics eNxitywayo: I-Enzyme-Based Body-Worn Electronic Devices. Acc. Ikhem. Res. 2018, 51, 11, 2820-2828. Umhla wokupapashwa: Novemba 6, 2018. DOI: https://doi.org/10.1021/acs.accounts.8b00451
- Huang, J., Xue, S., Buchmann, P. okqhubekayo. 2023. Ujongano lwe-electrogenetic kwiprogram ye-mammalian gene expression by ngqo ngoku. Ubume beMetabolism. Ipapashwe: 31 Julayi 2023. DOI: https://doi.org/10.1038/s42255-023-00850-7
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, it uses a DC supply to generate reactive oxygen species that act on synthetic promoters for expression. In a type 1 diabetic mouse model, the device stimulated subcutaneously implanted engineered human cells to release insulin that restored normal blood sugar level.){kind=link}