Ukuzila ukutya okuNgaphakathi okanye ukutya okuMiselwe ixesha (TRF) kuneziphumo ezibi kakhulu kwiiHormones

Ukuzila ukutya okwethutyana kunoluhlu olubanzi lweziphumo kwinkqubo ye-endocrine apho uninzi lunokuba yingozi. Ngoko ke, ukondla okunemiqathango yexesha (i-TRF) akufuneki kumiselwe ngokubanzi ngaphandle kokuba ingcali yezempilo ivavanye iindleko ezikhethekileyo kunye neenzuzo ukubona ukuba i-TRF ifanelekile na emntwini.

Uhlobo 2 Disifo seswekile (T2D) sisifo esiqhelekileyo, ngokuyinhloko sibangelwa I-insulini ukuchasa; I-T2D inegalelo elikhulu ekwandeni kokugula kunye nomngcipheko wokufa¹. Ukumelana ne-insulin kukunqongophala kokuphendula kweeseli zomzimba kwihomoni ye-insulin, ebonisa iiseli ukuba zithathe iswekile.². Kukho ugxininiso olubalulekileyo kwi-intermittent ukuzila ukudla (ukutya iimfuno zemihla ngemihla ngexesha eliqingqiweyo, njengokutya ukutya kosuku kwiiyure ezisi-8 endaweni yeeyure ezili-12) ngenxa yokusebenza kwayo njengokhetho lonyango lwesifo seswekile.¹. Ukuphazamiseka ukuzila ukudla, ekwabizwa ngokuba yi-time restricted feed (TRF), yamkelwe ngokubanzi kwishishini lezempilo kunye nokomelela. Nangona kunjalo, zininzi iziphumo ezibalulekileyo ze-TRF kwinkqubo ye-endocrine, uninzi lwayo olunokuba luncedo okanye lunokuba yingozi empilweni.

Uphononongo luthelekisa iiprofayili zehomoni zamadoda aqeqeshelwe ukuxhathisa ahlulwa angamaqela ama-2: Iqela le-TRF litya iikhalori zemihla ngemihla kwifestile yeyure ezisi-8 ngokuchasene neqela elitya iikhalori zemihla ngemihla kwifestile yeyure ye-13 (kucingelwa ukuba isidlo ngasinye sithatha iyure ye-1 ukuyidla)³. Iqela lolawulo libe nokuncipha kwe-insulin nge-13.3% ngelixa iqela le-TRF liye lehla nge-36.3%.³. Le mpembelelo imangalisayo ye-TRF yokunciphisa i-insulin ye-serum mhlawumbi ingunobangela weziphumo eziluncedo ze-TRF kubuntununtunu be-insulin, kwaye ikhokelele kwindima yayo njengokhetho lonyango olunokubakho lwe-T2D.

Iqela lolawulo libe nokunyuka kwe-1.3% kwi-insulin-like growth factor 1 (IGF-1) ngelixa iqela le-TRF line-12.9% yehla.³. I-IGF-1 yinto ebalulekileyo yokukhula ekhuthaza ukukhula kwezicubu kuwo wonke umzimba, njengengqondo, amathambo kunye nezihlunu.⁴Ngoko ke, ukunciphisa okubalulekileyo kwi-IGF-1 kunokuba nemiphumo emibi njengokunciphisa ukuxinana kwamathambo kunye nobunzima bemisipha kodwa kunokuthintela ukukhula kwamathumba akhoyo.

Iqela lolawulo liye lehla nge-2.9% kwi-cortisol ngelixa iqela le-TRF liye lanyuka nge-6.8%.³. Oku kunyuka kwe-cortisol kuya kwandisa i-catabolic, imiphumo yeprotheni ehlazisayo kwiithishu ezifana nezihlunu kodwa iya kwandisa i-lipolysis (ukuqhekeka kwamafutha omzimba ukwenzela amandla)⁵.

Iqela lolawulo libe nokunyuka kwe-1.3% kwi-testosterone epheleleyo ngelixa iqela le-TRF liye lancipha nge-20.7%.³. Oku kuncipha kakhulu kwe-testosterone evela kwi-TRF kunokubangela ukuncipha komsebenzi wesondo, ukuthembeka kwethambo kunye nemisipha kunye nomsebenzi wokuqonda ngenxa yoluhlu olubanzi lweziphumo kuluhlu lwezicubu.⁶.

Iqela lolawulo libe nokwanda kwe-1.5% kwi-triiodothyronine (T3) ngelixa iqela le-TRF liye lehla nge-10.7%.³. Oku kuncipha kwe-T3 kuya kunciphisa izinga le-metabolic kwaye kunokuba negalelo kuxinzelelo, ukudinwa, ukuncipha kwe-peripheral reflexes kunye nokuqhina.⁷ ngenxa yezenzo ze-physiological ze-T3.

Ukuqukumbela, ngamaxesha athile ukuzila ukudla inoluhlu olubanzi lweziphumo kwinkqubo ye-endocrine apho uninzi lunokuba yingozi. Ngoko ke, i-TRF akufuneki imiselwe ngokwesiqhelo ngaphandle kokuba ingcali yezempilo ivavanye iindleko ezikhethekileyo kunye nezibonelelo ukuze ibone ukuba i-TRF ifanelekile na emntwini.

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Iingxelo:  

1. Albosta, M., & Bakke, J. (2021). Ngethutyana ukuzila ukudla: ingaba ikhona indima kunyango lweswekile? Uphononongo lweencwadi kunye nesikhokelo sabagqirha bonyango oluphambili. Isifo seswekile seklinikhi kunye ne-endocrinology, 7(1), 3. https://doi.org/10.1186/s40842-020-00116-1 

2. NIDDKD, 2021. Ukumelana ne-insulin kunye ne-Prediabetes. Iyafumaneka kwi-intanethi https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance  

3. Moro, T., Tinsley, G., Bianco, A., Marcolin, G., Pacelli, QF, Battaglia, G., Palma, A., Gentil, P., Neri, M., & Paoli, A. ( 2016). Iziphumo zeeveki ezisibhozo zokutya okukhawulelwe ixesha (16/8) kwi-basal metabolism, amandla aphezulu, ukubunjwa komzimba, ukuvuvukala, kunye nemingcipheko ye-cardiovascular risk kumadoda aqeqeshwe ukuxhathisa. Ijenali yeyeza lokuguqulela, 14(1), 290. https://doi.org/10.1186/s12967-016-1044-0 

4. ULaron Z. (2001). I-insulin-efana ne-insulin factor 1 (IGF-1): i-hormone yokukhula. I molecular i-pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

5. Thau L, Gandhi J, Sharma S. Physiology, Cortisol. [Ihlaziywe ngo-2021 Feb 9]. Ku: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Ifumaneka kwi: https://www.ncbi.nlm.nih.gov/books/NBK538239/ 

6. Bain J. (2007). Ubuso obuninzi be testosterone. Ungenelelo lweklinikhi ekwaluphaleni, 2(4), 567-576. https://doi.org/10.2147/cia.s1417 

7. Armstrong M, Asuka E, Fingeret A. Physiology, Thyroid Function. [Ihlaziywe ngo-2020 ngoMeyi 21]. Ku: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Ifumaneka kwi: https://www.ncbi.nlm.nih.gov/books/NBK537039/ 

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