Isiphumo esibi seFructose kwisistim somzimba

Uphononongo olutsha lubonisa ukuba ukonyuka kokutya kwefructose (ishukela yeziqhamo) kunokuba nefuthe elibi kwi-immunity. Oku kongeza isizathu sokulumkisa ukutya kwe-fructose, ngokubhekiselele kwimiphumo yayo kwi-immune system.

I-Fructose yinto elula iswekile ifumaneka kwimithombo emininzi efana neziqhamo, iswekile yetafile, uju kunye neentlobo ezininzi zesiraphu. Ukutya kwe-Fructose kubonise ukunyuka okuthe gqolo, okubangelwa ikakhulu ngenxa yokusetyenziswa kweemali eziphezulu zesiraphu yengqolowa ye-fructose, ngakumbi kumazwe aseNtshona. I-Fructose yaziwa ukuba inxulunyaniswa nokutyeba, uhlobo lwe-2 yeswekile kunye nesifo sesibindi esingesiso esinxilisayo.¹. Oku kunokwenzeka ngenxa ye-fructose emzimbeni ohamba ngeendlela ezahlukeneyo ze-metabolic xa kuthelekiswa ne-glucose kwaye zilawulwa ngaphantsi kunezo ze-glucose; oku kukholelwa ukuba kukhokelela ekwandeni kokuhlanganiswa kwe-fatty acids ekhokelela kwiziphumo ezibi zempilo². Kwakhona, ngokwe-anecdotally, abantu “baqhelene” ngakumbi kwaye baziqhelanise neglucose enokuthi iphakamise ukuphathwa kakubi kwefructose.

Uphononongo lwakutsha nje lubonisa iindlela ekwenziwa ngazo fructose kubangela ukungasebenzi kakuhle kweeseli zomzimba¹. Olu phando luphonononga imiphumo ye-fructose kwiiseli zomzimba, ngakumbi i-monocytes. I-Monocytes ikhusela abantu ekuhlaselweni kwe-microbial kwaye iyingxenye ye-innate immune system³. Isixokelelwano esizalwa naso sithintela iintsholongwane ezihlasela umzimba⁴. Imiphumo emibi ye-fructose kwiiseli zomzimba zandisa uluhlu lweziphumo ezibi zezempilo ezichazwe kakuhle ze-fructose, ebonisa ukuba ukusetyenziswa kwe-fructose yokutya kusenokungabi luncedo kwimpilo yokuzivikela yomzimba. Nangona kunjalo, kubalulekile ukuchaza ukuba i-fructose kunye neziqhamo azitshintshi njengoko imithombo emininzi ye-fructose efana nesiraphu yengqolowa ephezulu ye-fructose ayinazo izondlo eziluncedo, kwaye kunokubakho iingenelo ezithile zokutya iziqhamo ezithile ezifana ne-fiber kunye ne-micronutrient intake enokuthi ibe ngaphezu kokutya. imingcipheko yefructose ehambelana nayo.

I-monocytes enyangwa ngefructose ibonise amanqanaba asezantsi e-glycolysis (indlela yokugaya efumana amandla ukuze iiseli zisetyenziswe) kangangokuba amanqanaba e-glycolysis asuka kwi-fructose ayephantse alingane ne-glycolysis kwiiseli ezingaphathwanga swekile kwaphela.¹. Ngaphezu koko, i-monocytes ephathwa nge-fructose yayinamazinga aphezulu okusetyenziswa kwe-oksijini (kwaye ke imfuno) kune-monocytes ephathwa ngeglucose.¹. I-monocyte ye-Fructose-cultured nayo yayinokuxhomekeka okuphezulu kwi-phosphorylation ene-oxidative kune-monocytes ene-glucose.¹. I-phosphorylation ye-oxidative yenza uxinzelelo lwe-oxidative ngokudala ii-radicals zamahhala⁵.

I-monocyte enyangwa nge-Fructose ibonise ukunqongophala kwe-metabolic adaptation¹. Unyango lwe-Fructose lunyuse iimpawu zokudumba ezifana ne-interleukins kunye ne-tumor necrosis factor kakhulu kunonyango lwe-glucose.¹. Oku kuxhaswa kukufumanisa ukuba i-fructose yokutya ikwandisa ukuvuvukala kwiigundane¹. Ngapha koko, i-monocytes enyangwa nge-fructose yayingaguquguqukiyo kwaye ixhomekeke kwimetabolism ye-oxidative yamandla.¹. Nangona kunjalo, i-T-cells (enye i-immune cell cell) ayizange ichaphazeleke kakubi yi-fructose ngokumalunga namanqaku okuvuvukala, kodwa i-fructose yaziwa ngokuba negalelo kwizifo ezinjengokutyeba, umhlaza kunye nesifo sesibindi esinamafutha angenalo utywala kwaye esi siphumo esitsha sandisa uluhlu lwezifo. Ubungozi obunokubakho befructose ngokubangela iziphumo ezingalunganga kumajoni omzimba¹. Olu phando lutsha lukwabonisa iziphumo ze-oxidative-stress kunye nefuthe lokuvuvukala kwe-fructose kwaye iphakamisa ukuba sesichengeni kweeseli ezibalulekileyo zokuzivikela: i-monocytes, xa usebenzisa i-fructose yamandla.¹. Ke ngoko, olu phononongo longeza isizathu sokulumkisa ukutya kwe-fructose, malunga neziphumo zayo kumajoni omzimba.

***

Iingxelo:  

1. B Jones, N., Blagih, J., Zani, F. okqhubekayo. I-Fructose ihlaziya i-glutamine-exhomekeke kwi-oxidative metabolism ukuxhasa ukuvutha okubangelwa yi-LPS. Nat Commun 12, 1209 (2021). https://doi.org/10.1038/s41467-021-21461-4 

2. Ilanga, i-SZ, i-Empie, i-MW Fructose imetabolism ebantwini- zeziphi izifundo ze-isotopic tracer zisixelela ntoni. Yondla Metab (Ezweni) 9, 89 (2012). https://doi.org/10.1186/1743-7075-9-89 

3. Karlmark, KR, Tacke, F., & Dunay, IR (2012). I-Monocytes kwimpilo kunye nezifo - i-Minireview. Ijenali yaseYurophu yeMicrobiology kunye ne-immunology, 2(2), 97-102. https://doi.org/10.1556/EuJMI.2.2012.2.1 

4. Alberts B, Johnson A, Lewis J, et al. Ibhayoloji yeMolekyuli yeSeli. Uhlelo lwesi-4. ENew York: iNzululwazi yaseGarland; 2002. I-Innate Immunity. Ifumaneka kwi: https://www.ncbi.nlm.nih.gov/books/NBK26846/ 

5. Speakman J., 2003. Phosphorylation oxidative, mitochondrial proton cycling, free-radical production and aging. Inkqubela phambili kwiSeli yokuguga kunye neGerontology. Umqulu 14, 2003, iphepha 35-68. DOI: https://doi.org/10.1016/S1566-3124(03)14003-5  

***