I-Minoxidil yePateni yobudoda ubunkqayi: Izigxina ezisezantsi zisebenza ngakumbi?

Ulingo oluthelekisa i-placebo, i-5% kunye ne-10% yesisombululo se-minoxidil kwi-scalp yamadoda afumana ipateni yamadoda ukuguqa ngokumangalisayo kufumaniseke ukuba ukusebenza kakuhle kweminoxidil bekungaxhomekekanga kwidosi njengoko i-5% yeminoxidil yayisebenza ngakumbi ekukhuleni kwakhona kweenwele kune-10% yeminoxidil.¹.

I-Topical minoxidil ngoku kuphela evunyiweyo impatho ngenxa ye-androgenetic alopecia (ipateni yamadoda ukuguqa) engawaguquliyo amanqanaba e-serum hormone, njengokuphela kolunye unyango oluvunyiweyo yi-finasteride yomlomo enciphisa imveliso engapheliyo yehomoni yamadoda enamandla, i-dihydrotestosterone.². Ngoko ke, olu unyango lunomdla omkhulu kuluntu olukhulu lwamadoda alwa ne-androgenetic alopecia (AGA).

Olu pho nonongo lubandakanya inani lamadoda angama-90 ane-AGA, abekwe kumaqela e-3: 0% (placebo), i-5% kunye ne-10% yonyango ngesisombululo se-minoxidil¹ (ukwenzela ireferensi, i-5% ye-minoxidil yeyona fomyula ixhaphakileyo kwezorhwebo). Unyango lwathatha iiveki ezingama-36, kwaye iqela le-placebo liye lafumana phantse utshintsho kwi-vertex (isithsaba) kunye nokubalwa kweenwele ezingaphambili.¹. Njengoko bekulindelekile, i-5% kunye ne-10% yamaqela e-minoxidil aphinde aphinde akhule¹. Nangona kunjalo, ngokumangalisayo, i-5% ye-minoxidil yayisebenza ngamaxesha angama-9 ekukhuliseni kwakhona iinwele ze-vertex kune-10% ye-minoxidil.¹. Ngaphaya koko, i-5% ye-minoxidil yayisebenza kancinci kune-10% ekukhuleni kwakhona kweenwele ezingaphambili.¹. Okokugqibela, ulusu ukucaphuka kunye nokuchithwa kweenwele (oku kubonwa kwiinwele ze-scalp ngaphambi kokukhula kwakhona ngexesha lonyango lwe-minoxidil) yayivelele kakhulu kwiqela le-10% le-minoxidil kuneqela le-5% le-minoxidil¹.

Ezi zinto zifunyanisiweyo ziyamangalisa kakhulu xa kujongwa ukuba kukho ubudlelwane bedosi-impendulo kunye nokwanda kwedosi ye iziyobisi ehambelana nokunyuka kwesiphumo esifunwayo sechiza kunye nokwanda kweziphumo ebezingalindelekanga, hayi ukuncipha kwesiphumo esinqwenelekayo njengoko kubonwe kolu phononongo. Ezi ziphumo zibonisa ukuba kunokubakho ugxininiso olufanelekileyo lwesisombululo se-minoxidil esibonelela ngokukhula kwakhona kweenwele kwi-scalp kunye nokwanda ngaphaya kwalo mqobo kunciphisa ukukhula kwakhona. Oku kuphakamisa ukuba ugxininiso oluphezulu lwe-minoxidil lufana ne-10% nangaphezulu enokufumaneka ngokulula kwi-intanethi kwaye isoloko ivavanywa kuluntu olunamava. ukulahleka kweenwele, kufuneka ziphetshwe njengoko zineeprofayili zokhuseleko ezimbi kunye neenzuzo ezincinci.

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Iingxelo:  

1. Ghonemy S Alarawi A., kunye noBessar, H. 2021. Ukusebenza kunye nokhuseleko lwe-10% entsha ye-topical minoxidil ngokuchasene ne-5% ye-topical minoxidil kunye ne-placebo kunyango lwe-alopecia ye-androgenetic yamadoda: uvavanyo lwe-trichoscopic. Ijenali yoNyango lweDermatological. Umqulu 32, 2021 – Umba 2. DOI: https://doi.org/10.1080/09546634.2019.1654070 

2. Ho CH, Sood T, Zito PM. Androgenetic Alopecia. [Ihlaziywe ngo-2021 ngoMeyi 5]. Ku: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Ifumaneka kwi: https://www.ncbi.nlm.nih.gov/books/NBK430924/ 

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