Uphononongo lwamawele lubonisa ukuba iiprobiotics ezibizayo nezidumileyo zinokungasebenzi ekunyangeni 'umkhuhlane wesisu' kubantwana abancinci.
I-Gastroenteritis okanye ebizwa ngokuba yi-'stomach flu ' ichaphazela izigidi zabantwana abancinci kwihlabathi liphela. Ibangelwa ziibhaktheriya , iintsholongwane okanye iiparasite kwaye nangona ingesiso isifo esisongela ubomi kodwa ngumthwalo omkhulu kunyango njengoko sisizathu esiqhelekileyo sokulaliswa esibhedlele. Akukho nyango lukhawulezileyo lwe-acute gastroenteritis yabantwana ngaphandle kokunika abantwana ulwelo ikakhulu ukuthintela ukuphelelwa ngamanzi emzimbeni, kunye namayeza athile okunyanga isicaphucaphu kunye nokuphumla ngokwaneleyo. Ekubeni kungekho nyango lufanelekileyo, oogqirha banika iiprobiotics ekunyangeni abantwana abane-acute gastroenteritis.
Ukuqonda nzulu nge-microbiome – izigidi zeebhaktheriya ezinobuhlobo, iintsholongwane, iifungi njl.njl. – ezikholelwa ukuba ziluncedo emzimbeni womntu kuye kwakhuthaza ukukhula kweeprobiotics. Iiprobiotics zizinto eziphilayo ezikhuselekileyo nezibizwa ngokuba ziibhaktheriya 'ezinobuhlobo' okanye 'ezilungileyo' ezikholelwa ukuba zilwa nosulelo lwesisu . Kukholelwa ukuba zibuyisela ulungelelwaniso oluqhelekileyo lweebhaktheriya kwinkqubo yethu yokugaya ukutya kwaye zikwanyusa amajoni ethu omzimba ngokuphucula inkqubo yethu yokuzikhusela. Izifundo ezininzi ezincinci zibonise ukuba iiprobiotics zinokuba luncedo kodwa iziphumo ezinjalo ziye zanciphisa.
Iiprobiotics azisebenzi emva kwayo yonke loo nto?
Uphononongo olutsha olunamandla olupapashwe kwiNew England Journal of Medicine , olubandakanya abantwana abali-1,000 (iinyanga ezi-3 ukuya kwiminyaka emi-4 ubudala) lunika ubungqina bokuqala bokuba iiprobiotics zisenokungabi yindlela engcono okanye eluncedo ngakumbi kubantwana abancinci. Ababhali bajonge ukuvelisa ubungqina obuqinisekileyo nokuba buxhasa okanye buchasa ukusetyenziswa kweeprobiotics kwiintsana kunye nabantwana abancinci abanesifo sokugabha esibukhali. Abaphandi bavavanye iiprobiotics ezichazwe rhoqo ezibizwa ngokuba yiLactobacillus rhamnosus GG (LGG) enenguqulelo efanelekileyo kwiintsana kunye nabantwana abancinci. Olu phononongo lubandakanye abantwana abangama-971 abanikwe unyango kwiminyaka engaphezu kwemi-3 ukususela ngo-2014 ukuya ku-2017 kwiindawo ezingxamisekileyo kwiindawo zonyango ezahlukeneyo kulo lonke elaseMelika. Abantwana bakhethwa ukuba babonisa iimpawu zesifo sokugabha ezifana nendle ekhululekileyo, ukuhlanza, urhudo okanye usulelo lwamathumbu. Umbandela wawukukuba babengatyanga naziphi na iiprobiotics ubuncinane kwiiveki ezimbini ezidlulileyo.
Isiqingatha sabantwana sikhethwe ngokungenamkhethe ukufumana i-LGG ye-probiotic kabini yonke imihla kangangeentsuku ezintlanu, abanye batya i-placebo ejongeka ngokufanayo. Ngaphandle koku, abantwana banikwa ukhathalelo oluqhelekileyo lwezonyango. Abaphandi okanye abazali bebengazi okwangoku ukuba ngabaphi abantwana abanikwe iiprobiotics. Kwabonwa ukuba bonke abantwana babonisa iimpawu ezifanayo kunye nokuchacha okufanayo - nokuba banikwe iiprobiotics okanye i-placebo - umzekelo umntwana ngamnye wayenorhudo iintsuku ezimbini. Kwenziwa uthelekiso phakathi kweentsana nabantwana abasacathulayo. Izigulana ezithathe iiprobiotics zavavanywa ukubona ukuba i-gastroenteritis yayibangelwa yintsholongwane okanye ibhaktheriya. Iprobiotic nayo yavavanywa ngokuzimeleyo ukucoceka kunye namandla. Abaphandi bafikelela kwisigqibo esinye kuphela-iprobiotic LGG ayenzanga mahluko. Iprobiotic ayikhange incede ekuthinteleni ukugabha okanye urhudo.
Kwisifundo sesibini esenziwe eKhanada nesipapashwe kwiNew England Journal of Medicine, abantwana abangama - 886 (abaneminyaka ephakathi kweenyanga ezi-3 ukuya kwiminyaka emi-2) ababenesifo se-gastroenteritis bafumana ikhosi yeentsuku ezintlanu ye-probiotic equlethe iLactobacillus rhamnosus R001 kunye neLactobacillus helveticus R0052 okanye i-placebo (ehlala inikwa eMzantsi Asia). Kolu phononongo akukho mahluko ubonwe phakathi kwamaqela amabini abantwana abanikwe i-probiotics okanye i-placebo.
Ezi zifundo zimbini eKhanada nase-United States zigqibe kwelokuba amayeza amabini athandwayo eprobiotic avavanyiweyo awazange abenampembelelo ebantwaneni kwaye ke ngoko kunokugqitywa kwelokuba iiprobiotics akufanele zisetyenziswe kwigastroenteritis ngoogqirha okanye ngabazali ngokwabo. Oogqirha kufuneka bathathele ingqalelo ngokupheleleyo obu bungqina kwaye kufuneka babandakanye okufanayo kwizicwangciso zokungenelela kwisifo sohudo sabantwana. Nangona kunjalo, ababhali bakwenza kucace ukuba izifundo zabo zimalunga neempembelelo ezimbini ezidumileyo kwi-gastroenteritis kubantwana abancinci kwaye ayifuni ukuba iiprobiotics kufuneka zipheliswe ngokupheleleyo kuyo yonke into. Nangona zikhuselekile, iiprobiotics zisaduru kwaye 'iipilisi ezinebhaktheriya' aziyomfuneko kwaye kungcono ukuba abantwana batye ukutya okulungileyo okufana neyogathi, iziqhamo okanye imifuno endaweni yoko.
Uphononongo olulolu hlobo lukwabalulekile ekwenzeni inkqubela-phambili ekupheliseni amayeza angenasiphumo. Iiprobiotics zithengiswa ukuze zisebenze kuzo zonke iintlobo zezigulo - ukusuka kwimpilo yokwetyisa ukuya ekutyebeni nakwintliziyo kunye nempilo yengqondo. Eli lishishini lezigidi zeerandi; nangona kunjalo, iingcali zikhuthaza ukuba kukho imfuneko yemimiselo engqongqo ejikeleze i-probiotics njengoko beza phantsi kwezongezo zokutya ezingafuni mvume ngokungafaniyo namanye amachiza angaphezulu kwe-counter. Kwaye uninzi lophando malunga nokulunga kweeprobiotics luncinci kwaye luyanciphisa kwaye alugqibeki kwaye alunabo nabuphi na ubungqina obuqinileyo. Ke ngoko, kuqwalaselwe ukuthandwa kweeprobiotics, kukho imfuneko yezifundo ezinkulu, ezikumgangatho ophezulu, ezizimeleyo nezinamandla ezifana nezi ukuze kufikelelwe kuzo naziphi na izigqibo ngokubanzi.
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Umthombo (s)
1. USchnadower D et al. 2018. I-Lactobacillus rhamnosus GG ngokuchasene ne-Placebo ye-Acute Gastroenteritis ebantwaneni. N Engl J Med. . https://doi.org/10.1056/NEJMoa1802598
2. Freedman SB et al. 2018. Uvavanyo oluneendawo ezininzi lweProbiotic edibeneyo yabantwana abaneGastroenteritis. N Engl J Med. 379. https://doi.org/10.1056/NEJMoa1802597
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Amagqabantshintshi zivaliwe.