IGF-1: Ukurhweba phakathi koMsebenzi woQoqosho kunye noMngcipheko woMhlaza

I-Insulin-like growth factor 1 (IGF-1) yinto evelele yokukhula eyenza ezininzi iziphumo ezikhuthaza ukukhula kwe-hormone yokukhula (GH) ngokuvuselela kwe-GH ye-IGF-1 ukukhululwa kwisibindi.¹. Ukubonakaliswa kwe-IGF-1 kukhuthaza ukukhula kunye nokusasazeka komhlaza kunye neziyobisi ziye zaphuhliswa ukuze zijolise kwi-IGF-1 receptor (IGF1R) ukunciphisa i-IGF-1 yokubonisa, nangona ingasebenzi ngenxa yokuchasana neziyobisi eziphuhliswayo kwizigulane.². I-IGF-1 yonyulwa ukuba ibe ngumngcipheko we-prostate umhlaza kunye namanqanaba aphezulu e-serum ye-IGF-1 adibene neentlobo ezahlukeneyo zomhlaza². Nangona kunjalo, ngenxa yeziphumo ezikhuthaza ukukhula, kubandakanywa kwingqondo, ukunciphisa i-IGF-1 ukubonakaliswa kwengqondo kuhambelana nokunyuka kwesifo se-Alzheimer (AD) kunye nomngcipheko we-dementia, ukuncipha kwengqondo, ukuxhalaba kunye nokudakumba.² ecebisa urhwebo phakathi komsebenzi wokuqonda kunye nomngcipheko womhlaza.

Iimpuku ezineserum encitshisiweyo IGF-1 babe nokusilela kwengqondo ezithi zijikwe xa i-IGF-1 ilawulwa kwiimpuku.². Zombini i-insulin receptor (IR) kunye ne-IGF1R ivuselela ulwahlulo lweeseli kwaye ngenxa yoko nokukhula komhlaza.². Ukufunda kunye nememori kufuna i-insulin / i-IGF-1 ukubonakaliswa kunye nokunyuka kwe-IGF-1 kuhambelana nokuphucula imemori kunye nokwandisa umthamo we-hippocampus.². Ngapha koko, kwi-Parkinson's disease (PD) abaguli abanamanqanaba aphantsi e-serum IGF-1, babenokusebenza kakubi kwimisebenzi yovavanyo lwengqondo.². Nangona kunjalo, umdla IGF-1 inokucotha ukucocwa kwe-beta-amyloid plaque enegalelo kwi-AD.², kodwa kubonakala kubungqina bokuba i-IGF-1 ngokubanzi i-pro-cognition, i-pro-neurogenesis kunye ne-neuroprotective.

Umzekelo ocacileyo wolu rhwebo lunciphisa umngcipheko we-AD phakathi umhlaza izigulana, kunye nokuba abaguli abadala abanomhlaza babenenkumbulo ephezulu kunye nesantya esisezantsi sokuhla komsebenzi wememori². Ke, kubonakala kukhuselekile ukuyicacisa loo nto IGF-1, njengezinto ezininzi, ineenzuzo kunye nemingcipheko ehambelana nayo kwaye akukho ndlela ilula yokuba "sempilweni" ngokulawula i-IGF-1 ngokuguqula indlela yokuphila efana nokuzila kunye nokunciphisa amandla okunciphisa ukugxilwa kwayo kwiserum, njengoko ukunciphisa ukugxila kwiserum kunokuba nayo. iziphumo zengqondo ezingalindelekanga zenza umntu "angabi sempilweni".

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Iingxelo:  

1. ULaron Z. (2001). I-insulin-efana ne-insulin factor 1 (IGF-1): i-hormone yokukhula. I molecular i-pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

2. I-Rosenzweig SA (2020). I-Evolution eqhubekayo ye-Insulin-like Growth Factor Signaling. F1000 Uphando, 9, F1000 Faculty Rev-205. https://doi.org/10.12688/f1000research.22198.1 

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