Impembelelo ye-Hypertrophic yokunyamezela ukuSebenza kunye neendlela ezinokwenzeka

Ukunyamezela, okanye umthambo "we-aerobic", ngokuqhelekileyo ujongwa njengentliziyo umzimba kwaye ayidibani ngokubanzi ne-hypertrophy ye-skeletal muscle. Umthambo wokunyamezela uchazwa njengokwenza umthwalo ophantsi kakhulu kwisihlunu ixesha elide, njengempembelelo yokubaleka kwimisipha yethole kodwa ikwabandakanya ukusetyenziswa kobunzima obulula ekuxhathiseni. umzimba. Nangona kunjalo, uphononongo lwakutsha nje, olucacisa i-pathologies ye-skeletal muscle kwiigundane zesifo seswekile, yafumanisa isiphumo se-hypertrophic yokunyamezela (kule meko, i-treadmill esebenza kwi-gastrocnemius muscle), nakwiigundane ezingenasifo seswekile. Kwakhona ichaza iiprotheni ezimbini ze-skeletal muscle, iLungu leNtsapho ye-Kinesin 5B (KIF5B) kunye neProtein edibeneyo yokuKhula i-43 (GAP-43), ukungasebenzi kwabo kwisifo sikashukela kunye nendlela ukunyamezela kokunyamezela kukhuthaza i-hypertrophy ye-skeletal muscle ngokusebenzisa le mizila ethile yeprotheni.

Kulo cwaningo, iigundane ze-52 zamadoda zahlulwa zibe ngamaqela e-4: ulawulo (olunempilo, olungenasifo sikashukela), ulawulo oluqeqeshelwe ukunyamezela, isifo sikashukela, i-diabetics eqeqeshelwa ukunyamezela. I-K1F5B, i-GAP-43 kunye ne-PAX7 (iiseli zesathelayithi zemisipha ezijongene nokuhlaziywa kwemisipha emva umzimba-umonakalo wemisipha owenziwe²) ubuninzi, kunye ne-gastrocnemius cross-sectional area (CSA) zibaliwe.

The ngesifo sikashukela Iqela elingaqeqeshwanga lalinomlinganiselo ophantsi we-gastrocnemius CSA xa kuthelekiswa neqela elingaqeqeshwanga lolawulo, kwaye phantse isiqingatha senani le-nuclei ye-muscle (myonuclei) kunye nesiqingatha sesithathu se-satellite cell (PAX7) yobuninzi beqela elingaqeqeshwanga. Oku kubonisa i-pathologies enkulu kwi-skeletal muscle ye-diabetics. Nangona kunjalo, iqela eliqeqeshiweyo lesifo seswekile lineeparamitha ezingcono kakhulu imisipha impilo, kwaye phantse i-CSA efanayo, i-myonuclei kunye ne-PAX7 yobuninzi njengolawulo olungaqeqeshwanga, iphakamisa impembelelo ebalulekileyo ye-hypertrophic yokunyamezela-ukuqeqeshwa kwe-muscle kunye nokukwazi ukulwa nempilo ye-pathologies ye-muscle ye-diabetes. Ulawulo olusempilweni oluqeqeshiweyo lwaluneparameters ye-muscle ephezulu kakhulu kuwo onke amanye amaqela, kunye ne-CSA ephezulu kakhulu, kunye ne-myonuclei kunye ne-PAX7 yobuninzi.

Iprotheyini ye-KIF5B yayinxulumene kakhulu kunye nenombolo ye-myonuclei kunye ne-CSA ye-muscle. I-KIF5B yayicinezelwe ngokulinganayo kwisifo seswekile kwaye ukunyamezela-ukuqeqeshwa kwandise kakhulu iprotheni. I-KIF5B ikholelwa ukuba inoxanduva lokubeka i-myonuclei kwisihlunu (imisipha ine-nuclei eninzi ngokungafaniyo nezinye iintlobo zeeseli kunye ne-myonuclei entsha inokudalwa nakubantu abadala ngeendlela ezinjengezo. ukumelana umzimba³). Ngapha koko, iprotheyini ye-GAP-43 nayo yadityaniswa ngokufanelekileyo kunye nenombolo ye-myonuclei kunye ne-CSA yemisipha. I-GAP-43 nayo yacinezelwa ngokuphakathi iswekile kunye nokunyamezela-ukuqeqeshwa kwandise kakhulu iprotheni. I-GAP-43 ikholelwa ukuba ibandakanyeka kulawulo lokuphatha i-calcium. Ke ngoko, ukunyuswa kwazo zombini iiproteni kwindawo yesihlunu se-gastrocnemius ngokunyamezela-uqeqesho lwe-muscle kubonakala ngathi kukubonelela ngesiphumo se-hypertrophic, ngokunokwenzeka ngale ndlela yeprotheyini kwaye olu phando lukwakhanyisela ngezinto ezinokubangela ukungasebenzi kakuhle kwamathambo emisipha efana ne-atrophy ebonwa kwizigulana zeswekile. .

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Iingxelo:  

1. I-Rahmati, M., Taherabadi, SJ 2021. Imiphumo yoqeqesho lokuzivocavoca kwi-Kinesin kunye ne-GAP-43 ibonakaliso kwi-skeletal muscle fibers ye-STZ-induced diabetic rats. Sci Rep 11, 9535. https://doi.org/10.1038/s41598-021-89106-6 

2. Sambasivan R, Yao R, et al 2011. I-Pax7-ebonisa iiseli zesathelayithi ziyimfuneko ekuvuseleleni imisipha yabantu abadala. Uphuhliso. 2011 Sep;138(17):3647-56. doi: https://doi.org/10.1242/dev.067587 . I-Erratum kwi: Uphuhliso. 2011 Okt;138(19):4333. PMID: 21828093. 

3. UBruusgaard JC, uJohansen IB, okqhubekayo 2010. I-Myonuclei efunyenwe ngokuzilolonga ngokugqithisileyo yandulela i-hypertrophy kwaye ayilahlekanga ekunciphiseni. Iinkqubo zeNational Academy of Sciences Aug 2010, 107 (34) 15111-15116; DOI: https://doi.org/10.1073/pnas.0913935107  

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