Ukusetyenziswa kwejeli yeempumlo njengendlela entsha yokwenza i-COVID-19 ngendlela yebhayoloji kwaye ithintele ukungena kwayo emzimbeni womntu kunokunceda ukuthintela usulelo lwale ntsholongwane eluntwini, ngaloo ndlela inceda kulawulo lwezifo kunye nolawulo.
Kwiinzame zokulawula Covid-19 Ubhubhani, iindlela ezininzi ziye zavela kwezi nyanga zimbalwa zidlulileyo, ukunxiba imaski yobuso kunye nokugcina umgama phakathi kwabaphezulu ukuza kuthi ga ngoku ukunqanda ukusasazeka kwe-COVID-19. isifo. Iilebhu ezininzi kwihlabathi liphela zikhangela iindlela zokulwa intsholongwane ebangela i-COVID-19, nokuba kungokuthintela ukosulela uluntu ngemiqobo yomzimba, yentlalo kunye nebhayoloji okanye ngokuphuhlisa amachiza anokwazi ukunyanga isifo.
Kweli nqaku, sixoxa ngenoveli kunye neendlela ezinomdla zebhayoloji zokuphelisa intsholongwane ebangela i-COVID-19, ngaphambi kokuba ingene emzimbeni womntu. Sonke siyazi ukuba intsholongwane esasaza i-COVID-19 ingena emzimbeni womntu ikakhulu ngeempumlo Ukudlula ngalo lonke ixesha umntu edibana namathontsi anentsholongwane kwindawo eyingqongileyo. Izazinzulu kwi-IIT Mumbai eIndiya zifumene isibonelelo kwiSebe lezeNzululwazi kunye neTekhnoloji- IBhodi yeNzululwazi kunye nobuNjineli (DST-SERB) ukusebenza kwiprojekthi, "Ukubanjwa okusekwe kwi-Antibody ka-2019-nCoV kunye nokusebenza kwayo kusetyenziswa ilipid-based in situ ijeli” (1).
Injongo yale projekthi kukuphuhlisa amajoni omzimba ngokuchasene nesizinda se-receptor esibophelelayo se-spike glycoprotein yesi sifo esibangela intsholongwane ye-COVID-19 ebandakanyekayo ekuqondeni isamkeli se-cell-surface receptor, eyile, i-zinc peptidase angiotensin-converting enzyme 2. Izilwa-buhlungu zaphuhliswa. iya kufakwa kwi-emulsion ye-unsaturated yamahhala e-acid-based emulsion elayishwe kwi-situ gels ukuze ingasebenzi intsholongwane kwindawo yokungena.
Ijeli eza kuphuhliswa ngasentla iya kusetyenziswa kwi ngeempumlo indawo yokungena, eyona ndawo iphambili yokungenwa yintsholongwane ye-COVID-19. Intsholongwane xa idibana nejeli iya kungasebenzi kwaye ibambeke ngaphakathi kwijeli, ngaloo ndlela ithintele ukungena kwayo kwijeli. Esi sisombululo sinokucetyiswa ukukhusela ukhuseleko lwabasebenzi bezempilo ngakumbi i-otolaryngologists (2, 3) abasengozini enkulu ngenxa yokunxibelelana ngokusondeleyo kunye ne-mucus membranes yendlela yokuphefumula ephezulu yabantu abosulelekileyo kunye nabantu abasebenzela ezinye iinkonzo ezibalulekileyo apho beza khona. ngokusondeleyo nabanye abasebenzi kunye noluntu. Le ndlela intsha inamandla okukhusela oogqirha kunye nabasebenzi bezempilo, ukunciphisa usulelo loluntu, ngaloo ndlela inceda kulawulo lwezifo nolawulo.
Nangona kunjalo, njengawo onke amanye amanyathelo, olu tshintsho luthile luza nemingeni yalo. Ukuveliswa kwezilwa-buhlungu ezichasene nomphezulu we-glycoprotein yentsholongwane ngobuninzi obaneleyo ngexesha elifutshane sesokuqala. Izinto zejeli ezisetyenzisiweyo kufuneka zibe yi-hypo-allergenic ebantwini kwaye ubuninzi bejeli elawulwa kwipaseji yeempumlo kufuneka ibekwe emgangathweni njengoko ukwenza ngaphantsi akunakunceda ukwenza intsholongwane ingasebenzi kakuhle kwaye ukuyenza kakhulu kunokukhokelela ekuvalelekeni kwepaseji yeempumlo. , kukhokelela kubunzima obunokubakho bokuphefumla. Kuya kuba ngumceli mngeni nangakumbi ukwenza isigqibo kunye nokulawula ubungakanani bejeli obufanelekileyo kwizigulana ezine-asthma kunye neziphazamiso ezinxulumene noko.
Nangona kunjalo, indlela yokusebenzisa ijeli esekwe ngeempumlo ukwenza ukuba intsholongwane ingasebenzi ngendlela yebhayoloji ibonakala iyintsha kwaye kufanelekile ukuyilandela ukuqonda ukusebenza kwayo ekulawuleni lo bhubhani.
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Iingxelo:
1. PIB, 2020. I-ID 1612161 yoRhulumente wase-Indiya https://pib.gov.in/PressReleseDetail.aspx?PRID=1612161
2. Vukkadala N,. njl. al, 2020. I-COVID-19 kunye ne-otolaryngologist - uphononongo olusekwe kubungqina bokuqala. . ILaryngoscope. 2020 Mar 26. DOI: https://doi.org/10.1002/lary.28672 [Epub ngaphambi kokuprinta].
3. Givi B., et al, 2020. Iingcebiso zoKhuseleko kuVavanyo kunye noTyando lweNtloko kunye neNtamo Ngexesha le-COVID-19 Pandemic. JAMA Otolaryngol Head Neck Surg. Ipapashwe kwi-intanethi nge-31 kaMatshi 2020. DOI: http://doi.org/10.1001/jamaoto.2020.0780
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