I-Interferon-β yoNyango lwe-COVID-19: Ulawulo olungaphantsi kwesikhumba lusebenza ngakumbi

Iziphumo ezivela kulingo lwe-phase2 zixhasa umbono wokuba ulawulo olungaphantsi kwe-IFN- β kunyango lwe-COVID-19 longeza isantya sokuchacha kwaye kunciphisa ukufa..

Imeko engaqhelekanga ethiwe thaca ngubhubhani we-COVID-19 iqinisekise ukuba kujongwe iindlela ezahlukeneyo zokunyanga iimeko ezimandundu ze-COVID-19. Amachiza amatsha amaninzi ayazanywa kwaye amayeza asele ekho asetyenziswa ngokutsha. Corticosteroids sele zifunyenwe ziluncedo. Unyango lwe-Interferon sele lusetyenziselwa usulelo lwentsholongwane olufana ne-hepatitis. Ngaba i-IFN ingasetyenziswa ngokuchasene ne-SARS CoV-2 kwi-COVID-19?  

Kulingo lwangaphambili, i-IFN ibonakalise ukuba isebenza ngokuchasene ne-SARS CoV kunye MERS iintsholongwane. NgoJulayi ka-2020, ulawulo lwe-Interferon-β ngokusebenzisa i-nebulisation (oko kukuthi i-pulmonary inhalation) indlela yaxelwa ukuba ibonisa iziphumo ezithembisayo ekunyangeni iimeko ezimandundu ze-COVID-19 ngokusekwe kwidatha evela kwisigaba sesi-2 solingo lwezonyango. ^1,2.  

Ngoku, ingxelo yamva nje esekwe kwidatha yenqanaba lesi-2 lolingo lwezonyango oluqhutywe kwizigulana ezili-112 ezine-COVID-19 esibhedlele ePitié-Salpêtrière eParis, eFransi icebisa ukuba ulawulo lwe-IFN-β ngokusebenzisa indlela engaphantsi kwecutaneous yonyusa izinga lokuchacha kwaye kunciphisa ukusweleka kwi-COVID-19. iimeko ³.   

I-Interferon (i-IFN) ziiprotheyini ezifihliweyo ziiseli zomkhosi ekuphenduleni usulelo lwentsholongwane umqondiso kwezinye iiseli zobukho bentsholongwane. Impendulo eyothusayo ebaxiweyo kwezinye izigulana ze-COVID-19 ifunyaniswa inxulunyaniswa nokuphazamiseka kokuphendula kwe-IFN-1 kunye nokuvalwa. IFN-β imfihlo. Isetyenziswa kwi iTshayina ukunyanga inyumoniya ngenxa ye-SARS CoV nangona kunjalo ukusetyenziswa kwayo akwenziwanga mgangathweni ⁴.  

Ulingo lwenqanaba lesi-3 lonyango lokusetyenziswa kwe-Interferon (IFN) kunyango lwezigulane ezimandundu ze-COVID-19 luyaqhubeka ngoku. Ukwamkelwa kuya kuxhomekeka ekubeni iziphumo zokugqibela ziphakathi koluhlu olwamkelekileyo oluchazwe ngabalawuli.   

***

Imithombo:   

1. I-NHS 2020. Iindaba- ichiza elitsalweyo lithintela abaguli be-COVID-19 ukuba babe mandundu kulingo lwaseSouthampton. Iposwe nge-20 kaJulayi 2020. Iyafumaneka kwi-intanethi https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx Ifikeleleke nge-12 kaFebruwari 2021.  

2. Monk PD., Marsden RJ., Tear VJ., et al., 2020. Ukhuseleko kunye nokusebenza kakuhle kwe-inhaled nebulised interferon beta-1a (SNG001) kunyango lwe-SARS-CoV-2 usulelo: i-randomized, double-blind, placebo- kulawulwa, isigaba sesi-2 solingo. ILancet Respiratory Medicine, iyafumaneka kwi-intanethi nge-12 kaNovemba 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7 

3. UDorgham K., Neumann AU., et al 2021. Uthathela ingqalelo unyango olulolwakho lwe-Interferon-β lwe-COVID-19. Ii-Agents ze-Antimicrobial Chemotherapy. Iposwe kwi-Intanethi nge-8 kaFebruwari 2021. DOI: https://doi.org/10.1128/AAC.00065-21  

4. UMary A., Hénaut L., Macq PY., et al 2020. Ingqiqo yoNyango lwe-COVID-19 nguNebulised Interferon-β-1b-Uphononongo loncwadi kunye namava obuqu angaphambili. Imida kwiPharmacology., 30 Novemba 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.  

***