The baphandi kwiZiko lezoNyango laseTel-Aviv iSourasky Medical Centre baphumelele ngokupheleleyo kwiilingo zeSigaba soku-I kusetyenziso lwe-CD24. protein zisiwe exosomes ukunyanga Covid-19.
Izazinzulu kwiZiko lezoNyango laseTel-Aviv Sourasky ziye zayila i-agent ye-bio-therapeutic esekwe kwi-exosomes (i-membrane bound vesicles) ethwele i-CD24 protein. Ezi exosomes zisebenza njengesithuthi sokuhanjiswa kwe-CD24 protein. I-exosomes equlathe i-CD24 iye yabekwa yodwa kwaye yacocwa kwiiseli ze-T-REx™-293 ezenziwe ngobunjineli bofuzo ukuze ziveze ngaphezulu kwe-CD24. Ukongeza, izazinzulu kwi-OncoImmune Inc. zibonise ukusetyenziswa kwe-CD24Fc (iprotein ye-fusion ye-CD24 kunye ne-Fc) njengonyango oluchasene Covid-19 kulingo lwezonyango.
I-CD24 luphawu lweprotheyini olubonakaliswe ukuba lugqithise kakhulu kwiintlobo ngeentlobo zabantu i cancer1 kwaye kuzingelwa izilwa-buhlungu ezithile ezilwa ne-CD24 ukulwa nomhlaza. Nangona kunjalo, okuxakayo, kwimeko ye-COVID-19, izazinzulu zizamile ukunika iprotein ye-CD24 ukuthintela ukudumba okubangelwa sisiphango se-cytokine kwaye ngaloo ndlela kucinezela isifo se-COVID-19. Ingqiqo emva kokusebenzisa i-CD24 ngokuchasene nesifo se-COVID-19 kwizigulana ezichaphazeleka ngokuphakathi ukuya kwisifo esiqatha kukuba i-CD24 iye yabandakanyeka ekulawuleni ngendlela engalunganga impendulo yokhuselo lomzimba kwimodeli yokulimala kwesibindi eyenziwe yi-acetaminophen.2, apho iimpuku eziswele iprotein ye-CD24 zafa ngelixa iimpuku eziqhelekileyo ezine-CD24 protein expression zisinda. Ukongeza, unyango nge-CD24Fc (i-CD24 idityaniswe neprotheni ye-Fc) ayinciphisi nje ukubonakaliswa kwe-IL-6 kunye nezinye ii-cytokines ezivuthayo kwi-rhesus macaques yaseTshayina (ChRMs) kunye nosulelo lwe-Simian Immune Virus.3, kodwa ikwakhusela kwinyumoniya ebangelwa yintsholongwane4.
Oku kuye kwabangela ukuba abaphandi basebenzise i-CD24 protein ukunqanda ukudumba okubangelwa sisifo se-COVID-19. Ngelixa izazinzulu kwi-OncoImmune Inc. ziye zasebenzisa i-CD24Fc (ihanjiswa njenge-IV yokungena kwi-saline eqhelekileyo) kwi-randomized, i-double-blind, i-placebo-controlled, i-multi-site, isifundo seSigaba III.5 ukuvavanya ukhuseleko lwayo kunye nokusebenza kwayo ngokuchasene ne-COVID-19, abaphandi kwiZiko lezoNyango laseTel-Aviv Sourasky baphumelele ngokupheleleyo kwiilingo zeSigaba soku-I.6 ukuze kusetyenziswe iprotein ye-CD24 eziswe kwii-exosomes ukunyanga i-COVID-19. I-EXO-CD24 isetyenziswe kwizigulane ezingama-35 njenge-aerosolized kwi-saline eqhelekileyo yokuphefumla. Bonke abaguli abangama-30 baphola kwaye abangama-29 kubo baphola kwiintsuku ezi-3-5. Ezi ziphumo zikhuthazayo ziqinisekisa ulingo olongezelelweyo lweSigaba sesi-II kunye nesigaba sesi-III ukuze siqinisekise ngakumbi ukhuseleko lwaso nokusebenza kakuhle kwaye sivumele ukuba samkelwe ngabalawuli ukuba sisetyenziswe kwizigulana ze-COVID-19.
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Ucaphulo
- Shapira, S., Finkelshtein, E., Kazanov, D. okqhubekayo. Iipeptides eziphuma kwi-Integrase kunye ne-CD24-targeted lentiviral particles zithintela ukukhula kwe-CD24 ebonakalisa iiseli zomhlaza. oncogene (2021). https://doi.org/10.1038/s41388-021-01779-5
- I-Chen GY, i-Tang J, i-Zheng P, i-Liu Y. CD24 kunye ne-Siglec-10 ngokukhethayo bacinezele iimpendulo ze-immune ezibangelwa ngumonakalo wezicubu. Inzululwazi. 2009 Mar 27;323(5922):1722-5. DOI: https://doi.org/ 10.1126/science.1168988. Epub 2009 Mar 5.
- Tian RR, Zhang MX, Zhang LT, Zhang P, Ma JP, Liu M, Devenport M, Zheng P, Zhang XL, Lian XD, Ye M, Zheng HY, Pang W, Zhang GH, Zhang LG, Liu Y, Zheng YT . I-CD24 kunye ne-Fc fusion protein ikhusela i-SIVmac239-eyosulelwe yi-rhesus macaque yaseTshayina ngokuchasene nokuqhubekela phambili kwi-AIDS. I-Antiviral Res. 2018 Sep;157:9-17. DOI: https://doi.org/10.1016/j.antiviral.2018.07.004. Epub 2018 Jul 3.
- I-Tian RR, i-Zhang MX, i-Liu M, i-Fang X, i-Li D, i-Zhang L, i-Zheng P, i-Zheng YT, i-Liu Y. CD24Fc ikhusela i-pneumonia ye-viral kwi-simian immunodeficiency virus-esulelwe yi-rhesus monkeys yaseTshayina. Iseli Mol Immunol. 2020 Aug;17(8):887-888. DOI: https://doi.org/ 10.1038/s41423-020-0452-5. Epub 2020 May 7.
- I-CD24Fc njenge-Non-antiviral Immunomodulator kuNyango lwe-COVID-19 (SAC-COVID). Iyafumaneka kwi-intanethi https://clinicaltrials.gov/ct2/show/NCT04317040
- UVavanyo loKhuseleko lwe-CD24-Exosomes kwizigulana ezinosulelo lwe-COVID-19. Iyafumaneka kwi-intanethi https://clinicaltrials.gov/ct2/show/NCT04747574
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