Imeko elungiswayo ngokulula ye Ukunqongophala kweVithamini D (VDI) ineziphumo ezibi kakhulu ze-COVID-19. Kumazwe achatshazelwe kakhulu yi-COVID-19 njenge-Itali, iSpain kunye neGrisi, Vitamin Amazinga okungabikho kwe-D (VDI) ayephezulu kuluhlu lwe-70-90%. kwelinye icala, eNorway naseDenmark, apho i-COVID-19 yayingaphantsi kakhulu, amaxabiso e-VDI ayeyi-15-30% ebonisa ulungelelwaniso olomeleleyo phakathi kwe-VDI kunye ne-COVID-19. Kucingelwa ukuba i-VDI iyenza mandundu ubungqongqo be-COVID-19 ngeziphumo zayo zeprothrombic kunye nokupheliswa kokuphendula komzimba. Ngaphaya koko, e-Wuhan, i-COVID-19 Associated Coagulopathy (CAC) yayikhona kwi-71.4% yabantu abangasindiyo vs. 0.6% kwabasindileyo. Izigulana ezine-VDI ezineempawu eziqatha ze-COVID-19 nazo zine-CAC, oko kukuthi. ukujiya kwegazi kwimithambo emincinci eyayanyaniswa nokufa okuphezulu.
The Covid-19 Ubhubhani osulele abantu abazizigidi ezi-6.4 kwihlabathi liphela kwaye wakhokelela ekuswelekeni kwabantu abangama-380,000 uzise umhlaba wonke emadolweni awo malunga nemeko yezoqoqosho. Njengoko isitofu sokugonya sisabonwa, kukho imfuneko yokuqonda nzulu kwesi sifo ukuze kuthatyathwe amanyathelo okhuseleko aneleyo ukuthintela ukonganyelwa sesi sifo. Intetho yakudala, "Uthintelo lungcono kunokunyanga", ilunge kakhulu kwimeko yesifo se-COVID-19 njengoko lonke ilizwe lezenzululwazi lizama ukuqonda ubume kunye nobunzima besi sifo ukuze kufumaneke amanyathelo okuthintela ukusasazeka kwaso.
Izifundo ezininzi zenziwe ukuqonda umjikelo wobomi bentsholongwane ye-SARS-CoV-2, ubugwenxa bayo kubantu abakubudala obahlukeneyo kunye nenqanaba lokuchacha kwabantu abosulelwe yile ntsholongwane.1,2. Enye yezinto ebezinokungahoywa yi Vitamin Imo ye-D yabemi enokuthi ichaphazele ubungqongqo besifo se-COVID-19 njengoko abantu abaninzi becetyiswa ukuba bahlale ezindlini. Kwizifundo kulo lonke elaseYurophu, kuye kwaphawulwa ukuba i-COVID-19 yayinzima e-Itali, eSpain naseGrisi eyayinayo vitamin D ukungoneli (VDI) amazinga angama-70-90% xa kuthelekiswa ne-VDI ye-15-30% eNorway naseDenmark apho isifo se-COVID-19 sasingekho ezinzima 3. Ukutya kwabantu kumazwe aseScandinavia kutyebile Vitamin D ngenxa yokutyiwa kweentlanzi ezinamafutha aphezulu kunye nezongezo zobisi ezomelezwe ngeVithamin D3.
Kuphononongo lwakutsha nje olwenziwa kwiziko lezonyango elikwinqanaba eliphezulu kwizifundo ezingama-20, kwafunyanwa unxulumano oluthe ngqo phakathi kwamanqanaba Vitamin D kunye nobuzaza besifo se-COVID-19. I-11 yezi zigulana zamkelwa kwi-ICU kwaye zine-VDI, isi-7 kuzo sinamanqanaba angaphantsi kwama-20ng/mL ngelixa ukuphumla kunamanqanaba asezantsi nangaphantsi. Izigulana ezili-11 kwi-ICU, iipesenti ezingama-62.5 zine-CAC (COVID-19 Associated Coagulopathy) ngelixa i-92.5% ine-lymphopenia ecebisa ukuba i-VDI yenza mandundu ubungqongqo be-COVID-19 ngeziphumo zayo ze-prothrombic kunye nokupheliswa kokuphendula komzimba.4. E-Wuhan, i-CAC yayikhona kwi-71.4% yabantu abangasindiyo vs. 0.6% kwabasindileyo.5. Vitamin I-D ibonakaliswe ukuba idlala indima ebalulekileyo ekumodareyitheni impendulo yangaphakathi kunye ne-adaptive immune immune6, 7 ngelixa i-VDI inxulunyaniswa nomngcipheko owongeziweyo we-CVD kunye nokufa8.
Kolunye uphononongo lwamaziko amaninzi angama-212 anosulelo oluqinisekiswe yilabhoratri ye-SARS-CoV-2, i-serum. vitamin D amanqanaba ebesezantsi kwiimeko ezimandundu, kodwa aphezulu kwiimeko ezingephi9. Uhlalutyo lwedatha lubonise ukuba kwinqanaba ngalinye ukunyuka kokutenxa kwiserum i vithamini D, amathuba okuba nesiphumo esincinci seklinikhi kunokuba esibi kakhulu anyuswe ~ 7.94 amaxesha, ngelixa okuthakazelisayo, amathuba okuba nesiphumo esincinci seklinikhi kunokuba isiphumo esibalulekileyo sanyuswa ~ 19.61 amaxesha9. Oku kuphakamisa ukuba ukunyuka kwamanqanaba e-vitamin D emzimbeni kunokuphucula iziphumo zeklinikhi, ngelixa ukwehla i vithamini Amanqanaba e-D emzimbeni anokomeleza iziphumo zeklinikhi kwizigulana ze-COVID-19.
Olu phononongo lubonisa impendulo eqinisekileyo/ephuculweyo yezonyango kwizigulana ze-COVID-19 ezinamazinga anyukileyo i vithamini D kunye nempendulo yeklinikhi engalunganga / engalunganga ephantsi i vithamini Amanqanaba e-D aqinisekisa uphando oluthe kratya ngendima ye i vithamini D kwi-COVID-19 isifo kwaye ibonelela ngendlela eya phambili koogqirha kunye nabenzi bomgaqo-nkqubo ukuba benze ulingo lwabantu abaninzi ukuvavanya oku njengendlela yokuthintela ukulwa ne-COVID-19.
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Iingxelo:
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5. Tang N, Li D, et al 2020. Iiparamitha ezingaqhelekanga ze-coagulation zinxulunyaniswa ne-prognosis embi kwizigulana ezinenoveli coronavirus pneumonia. Ijenali yeThrombosis kunye neHaemostasis 18, 844-847 (2020). Ipapashwe okokuqala: 19 February 2020. DOI: https://doi.org/10.1111/jth.14768
6. ULiu PT., Stenger S., et al. 2006. I-toll-like receptor triggering ye-vitamin D-mediated human antimicrobial response. Inzululwazi 311, 1770-1773 (2006). DOI: https://doi.org/10.1126/science.1123933
7. U-Edfeldt K., uLiu PT., et al 2010. Ii-cytokines ze-T-cell ngokwahlukileyo zilawula iimpendulo ze-antimicrobial ye-monocyte yabantu ngokulawula i-vitamin D metabolism. Iproc. Natl. Akhad. Sci. I-USA 107, 22593-22598 (2010). DOI: https://doi.org/10.1073/pnas.1011624108
8. Forrest KYZ kunye ne-Stuhldreher WL 2011. Ukuxhaphaka kunye nokulungelelaniswa kokungabikho kwe-vitamin D kubantu abadala base-US. Uphando lwezondlo 31, 48-54 (2011). DOI: https://doi.org/10.1016/j.nutres.2010.12.001
9. Alipio M., 2020. Ufakelo lweVithamini D lunokuthi luphucule iziPhumo zoNyango lwezigulana ezosulelwe yi-Coronavirus-2019 (COVID-19) (nge-9 ka-Epreli 2020). Ifumaneka e https://www.semanticscholar.org/paper/Vitamin-D-Supplementation-Could-Possibly-Improve-of-Alipio/089f3d71cb60ea4936c1448945e228a8346fa276
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