Uphononongo oluninzi lubonisa ukuba ukusebenza kwe-NLRP3 inflammasome kunoxanduva lwe-acute respiratory distress syndrome kunye/okanye ukwenzakala okubukhali kwemiphunga (ARDS/ALI) okubonwa kwizigulana ezigula kakhulu ze-COVID-19 ezihlala zikhokelela ekufeni ngenxa yokusilela kwamalungu amaninzi. Oku kubonisa ukuba i-NLRP3 inokuba idlala indima ebaluleke kakhulu kwikhosi yezonyango. Ke ngoko, kukho imfuneko engxamisekileyo yokubeka le ngqikelelo ukuvavanya ukujonga i-NLRP3 njengento ekujoliswe kuyo ichiza ukulwa ne-COVID-19.
Isifo se-COVID-19 sidlale umonakalo kwihlabathi jikelele sichaphazela izigidi zobomi kwaye siphazamisa uqoqosho lwehlabathi liphela. Abaphandi kumazwe aliqela basebenza ngokuchasene nexesha ukufumana unyango lokulwa i-COVID-19 ukuze abantu banyangeke ngokukhawuleza kwaye ubuqhetseba bubuyiselwe. Amacebo angundoqo asetyenziswayo ngoku aquka ukuphuhlisa inoveli kunye nokuphinda kusetyenziswe amachiza asele ekhona1,2 ezisekwe phezu, ekujoliswe kuko kwechiza elichongwe ngokuphonononga ukudibana komkhosi wentsholongwane egazini, kujoliswe kwiiproteni zentsholongwane ukubamba ukuphindaphindeka kwentsholongwane kunye nophuhliso lwesitofu. Qonda i-pathology yesifo se-COVID-19 ngokweenkcukacha ezithe vetshe ngokuqonda indlela yokusebenza kwayo, kunokukhokelela ekuchongweni kweethagethi zamachiza anoveli anokuthi asetyenziswe ekuphuhliseni amatsha kunye nenjongo ekhoyo. iziyobisi ngokuchasene noku kujoliswe kuko.
Ngelixa uninzi (~80%) lwezigulana ze-COVID-19 ziba nomkhuhlane ongephi, ukukhohlela, ukuqaqanjelwa zizihlunu kunye nokuchacha kwisithuba seentsuku ezili-14-38, uninzi kakhulu Izigulana ezigulayo kunye nabo bangabuyiyo bahlakulela isifo esibuhlungu sokuphefumla kunye / okanye ukwenzakala kwimiphunga ebukhali (ARDS / ALI), ekhokelela kukusilela kwamalungu amaninzi okukhokelela ekufeni.3. Isaqhwithi seCytokine siye sabandakanyeka kuphuhliso lwe-ARDS/ALI4. Esi siqhwithi se-cytokine sinokuthi siqhutywe kusebenze kwe-NLRP3 inflammasome (i-multimeric protein complex eqala iimpendulo ezivuthayo xa kusebenze i-stimuli eyahlukeneyo.5) ngeeproteni ze-SARS-CoV-26-9 echaphazela i-NLRP3 njengenxalenye enkulu ye-pathophysiological kuphuhliso lwe-ARDS/ALI10-14, okukhokelela ekungaphumeleli kokuphefumla kwizigulane.
I-NLRP3 idlala indima ebalulekileyo kwisixokelelwano esizalwa naso. Kwimeko eqhelekileyo ye-physiological, i-NLRP3 ikhona kwimeko engasebenziyo eboshwe ngamaprotheni athile kwi-cytoplasm. Ekusebenzeni ngokuvuselela, kubangela iimpendulo ezivuthayo ezibangela ukufa kweeseli ezosulelekileyo eziye zacinywa kwinkqubo, kwaye i-NLRP3 ibuyela kwimeko yayo yokungasebenzi. I-NLRP3 i-inflammasome inegalelo ekusebenzeni kweplatelet, ukuhlanganiswa kunye nokwakhiwa kwe-thrombus kwi-vitro.15. Nangona kunjalo, kwimeko ye-pathophysiological efana nosulelo lwe-COVID-19, ukusebenza ngokungasebenziyo kwe-NLRP3 kwenzeka kubangele isaqhwithi se-cytokine. Ukukhutshwa kwe-cytokines ye-proinflammatory kubangela ukungena kwi-alveoli kwimiphunga ekhokelela ekudumbeni kwe-pulmonary egcweleyo kunye nokusilela kokuphefumla okulandelayo kodwa kunokubangela i-thrombosis ngokugqabhuka kwamacwecwe kwiinqanawa ngenxa yokudumba. Ukudumba kwezihlunu zentliziyo bekukwinxalenye enkulu yezigulana ezilaliswe esibhedlele nge-COVID-1916.
Ukongeza, i-NLRP3 i-inflammasome ibonakalisiwe, ekukhuthazeni okuthe ngqo, ukuthatha inxaxheba kwi-pathogenesis ye-infertility yamadoda ngokufakwa kwe-cytokine evuthayo kwiiseli ze-Sertoli.17.
Ke ngoko, ngokujonga ezi ndima zikhankanywe ngasentla, i-NLRP3 inflammasome ibonakala idlala indima ebaluleke kakhulu kwikhosi yezigulana ze-COVID-19 ezigula kakhulu. Ke ngoko, kukho imfuneko engxamisekileyo yokubeka le ngqikelelo ukuvavanya ukujonga i-NLRP3 inflammasome njengento ekujoliswe kuyo ichiza ukulwa ne-COVID-19. Le ngqikelelo ivavanywa zizazinzulu zaseGrike ezicwangcise uphononongo lolingo lweklinikhi olungacwangciswanga olubizwa ngokuba yi-GRECCO-19 ukuphanda iziphumo ezithintelayo ze-colchicine kwi-NLRP3 inflammasome.18.
Ukongeza, izifundo malunga neendima ze-NLRP3 inflammasome ziya kubonelela ngolwazi olongezelelekileyo malunga ne-pathology kunye nokuqhubeka kwesifo se-COVID-19. Oku kuya kunceda oogqirha ukuba balawule ngcono izigulana ngakumbi ezo zine-co-morbidities ezifana nesifo senhliziyo kunye nezigulana esele zikhulile. Kwizigulane ezisele zikhulile, iziphene ezinxulumene nobudala kwiiseli ze-T kunye ne-B zibangela ukwanda kokubonakaliswa kwe-cytokines, okukhokelela kwiimpendulo ezithatha ixesha elide zokudumba, ezinokukhokelela kwisiphumo esibi seklinikhi.16.
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