I-Nitric oxide (NO): Isixhobo esitsha sokulwa ne-COVID-19

Iziphumo ezivela kuvavanyo lweklinikhi lwesigaba sesi-2 esandula kugqitywa eCanada kunye ne UK cebisa i-nitric oxide (NO) inokuba luncedo kakhulu ekuthinteleni nasekunyangeni Covid-19.

I-nitric oxide NO, (ayinakubhidaniswa ne-nitrous oxide N₂I-O esetyenziswa njenge-anesthetic kwiimeko zeklinikhi) ekwabizwa ngokuba yi-endothelium-derived relaxing factor (EDRF) yimolekyuli eyaziwayo yebhayoloji ebonisa i-endogenous kwaye idlala indima ebalulekileyo ekuphumleni izihlunu ezigudileyo. igazi isitya esikhokelela kwi-vasodilation kunye nokunyuka kwegazi. Iqhele ukusetyenziswa njengeprodrug Glyceryl trinitrate GTN ukukhulula iintlungu zesifuba (angina). I-Sildenafil (i-Viagra) isebenzisa indlela efanayo ye-nitric acid ye-vasodilation.  

Enye ipropathi ephononongwa kancinci ye-nitric oxide (NO) ngumsebenzi wayo we-antimicrobial ngokuchasene noluhlu lweentsholongwane ezibandakanya intsholongwane uxanduva lwezifo zokuphefumla ezifana ne-pneumonia esibhedlele. I-nitric oxide nayo yafunyaniswa ineempawu ezibalulekileyo zokulwa neentsholongwane. AKUKHO ukuphefumla okubonakalisiweyo ukuphucula imeko ye izigulane uchatshazelwa yi-SARS.  

Kuba i-SARS-CoV2 inxulumene ngokwemfuza ne-SARS-CoV, bekucingelwa ukuba HAYI inokusebenza ngokuchasene. I-SARS-CoV2 njengokuba ^1,2. Imeko yeklinikhi embi ebonwa kuyo Covid-19 kungenxa yokuba i-SARS-CoV2 ibangela ukungasebenzi kakuhle kwe-nitric oxide (NO) kwiiseli kunye nezicubu ezikhokelela ekunciphiseni inqanaba le-NO kunye ne-bioavailability. Ke ngoko, ukomeleza ukufumaneka kwe-nitric oxide (NO) ngokuphandle ngeendlela ezifanelekileyo ezinje ngokuphefumlela, ukutshiza ngeempumlo, ukugabha, ukukhupha izisombululo njl.njl kufuneka kuncede izigulana ze-COVID-19.³.  

Okwangoku, amalingo amaninzi ekliniki ayaqhuba ukuvavanya ukusebenza kwe-NO njengearhente yonyango kunye nothintelo lokulawula i-COVID-19. Izifundo ezibalulekileyo zingezantsi- 

Inhalation: Unyango lokuphefumla irhasi ye-Nitric Oxide ye-COVID-19 ePhakathi/ePhakathi (NoCovid): Olu lingo lwenqanaba lesi-2 luxhaswa ngezimali siSibhedlele Jikelele saseMassachusetts kwaye sivavanya ukuba ukuphefumla i-nitric oxide (NO) kuyakuthintela ukuqhubela phambili kwizigulana ezine-COVID-19 ephakathi ukuya kwephakathi.  AKUKHO uThintelo lwe-COVID-19 kubaBoneleli bezeMpilo (NOpreventCOVID) lolunye uphononongo olwenziwa yiMassachusetts General Hospital kwaye yenzelwe ukuvavanya ukuba irhasi ye-nitric oxide inhalation iyayithintela i-COVID-19 phakathi kwabasebenzi bezempilo.  

Ukutshiza ngeempumlo: I-Nitric Oxide Nesal Spray yonyango lwe-COVID-19: Ixhaswe yiAshford kunye neSt Peter's Hospitals NHS Foundation Trust, olu phononongo lujolise ekuvavanyeni ukuba ingaba i-nitric oxide (NO) ihanjiswe ngesitshizi seempumlo iyanyanga iimpawu ze-COVID-19 ezibuthathaka.  

Ukukhupha izisombululo: INitric oxide ekhupha izisombululo zokuThintela kunye nokuNyanga ukosuleleka kwe-COVID-19 ePhakathi/ePhakathi (NOCOVID) ixhaswe yi-SaNOtize, olulingo lwezonyango lwe-phase2 lwenziwa eCanada kwaye lugqityiwe. Uphononongo luvavanye ukusebenza kobumnini be-NORS (iNitric Oxide Releasing Solution) ekuyilweni nasekunyangeni usulelo oluphakathi/ oluphakathi.^4,5.  

Njengokukhutshwa kweendaba nge-SaNOtize, isisombululo esikhuphayo i-NORS yanciphisa umthamo wentsholongwane egazini ngaphezu kwe-95% kubathathi-nxaxheba abosulelekileyo kwiiyure ezingama-24 zonyango, kwaye ngaphezu kwe-99% kwiiyure ezingama-72. Unyango lukhawulezise ukucocwa kwe-SARS-CoV-2 ngokuphindwe kayi-16 xa kuthelekiswa ne-placebo ekhuthaza ngokwenene. Inkampani icwangcisa ukungeniswa koGunyaziso lokuSebenzisa oluNgxamisekileyo e-UK naseCanada ngokukhawuleza⁶.  

Ithemba lokuphinda lisetyenziswe nge-Nitric Oxide (NO) ingqina ukuba iluncedo ekuthinteleni nasekunyangeni Covid-19 iimeko ngokukhawuleza.  

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Iingxelo: 

1. UGianni S., Fakhr BS., et al 2020. Ukuphefumla igesi ye-nitric oxide ukuthintela i-COVID-2019 kubaboneleli bezempilo. Ukuprintwa kwangaphambili. MedRxiv. Iposwe nge-11 ka-Epreli 2020. DOI: https://doi.org/10.1101/2020.04.05.20054544 

2. Pieretti JC., Rubilar O., et al 2021. I-nitric oxide (NO) kunye ne-nanoparticles - Izixhobo ezincinci ezinokwenzeka zokulwa ne-COVID-19 kunye nolunye usulelo lwe-coronavirus yabantu. UPhando lweNtsholongwane. Umqulu 291, 2 January 2021, 198202. DOI: https://doi.org/10.1016/j.virusres.2020.198202 

3. UFang W., Jiang J., okqhubekayo 2021. Indima ka-NO kwi-COVID-19 kunye nezicwangciso zonyango ezinokubakho. Ibhayoloji yeRadical yasimahla kunye neMediza. Umqulu 163, iphepha 153-162. Ipapashwe nge-1 kaFebruwari 2021. DOI:https://doi.org/10.1016/j.freeradbiomed.2020.12.008 

4. I-US NLM 2021. I-Nitric oxide ekhupha izisombululo zokuThintela kunye nokuNyanga ukosuleleka kwe-COVID-19 okuPhakathi/ okuPhakathi (NOCOVID). Isazisi seClinicalTrials.gov: NCT04337918. Iyafumaneka kwi-intanethi https://www.clinicaltrials.gov/ct2/show/NCT04337918?term=SaNOtize+nasal+spray&cond=Covid19&draw=2&rank=2 Ifikeleleke nge-08 ka-Epreli 2021.  

5. SaNOtize, 2021. NORSTM - iteknoloji yethu yeqonga. Iyafumaneka kwi-intanethi https://sanotize.com Ifikeleleke nge-08 ka-Epreli 2021.  

6. SaNOtize, 2021. Ukukhutshwa kweendaba-UK Ulingo lwezonyango luqinisekisa uNyango lweSaNOtize oluQhelekileyo lwe-COVID19. Iyafumaneka kwi-intanethi https://www.businesswire.com/news/home/20210315005197/en/UK-Clinical-Trial-Confirms-SaNOtize’s-Breakthrough-Treatment-for-COVID-19 Ifikeleleke nge-08 ka-Epreli 2021.  

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