NeoCoV, a intsholongwane ye-Corona Uxinzelelo olunxulumene ne-MERS-CoV efunyenwe kumalulwane (i-NeoCoV ayisiyonto intsha ye-SARS-CoV-2, umntu intsholongwane ye-Corona uhlobo olujongene nobhubhane we-COVID-19) kuxelwe ukuba yimeko yokuqala yokwahluka kwe-MERS-CoV kusetyenziswa i-ACE2. I-NeoCoV inokubanakho ukuvela komntu ngokufa okuphezulu kunye nesantya sosulelo.
I-NeoCoV luxinzelelo olunxulumene ne-MERS-CoV esebenzisa ilulwane I-ACE 2 i-receptors yokungena kwayo kunye nosulelo kwiiseli zelulwane. Nangona kunjalo, iingxaki ze I-MERS-CoV isebenzisa ii-receptors ze-DPP4 zokungena kwiselula. Kubalulekile ukuqaphela ukuba i-NeoCoV ayisiyonto intsha SARS-selwe-2 oko kubangele ubhubhani wehlabathi liphela ukusukela oko wavela ngoNovemba ka-2019.
Eli nqaku libonisa ukuba i-NeoCoV kunye nesihlobo sayo esisondeleyo se-PDF-2180-CoV siyakwazi ukubophelela ngokufanelekileyo kwi-ACE 2 i-receptors kwi-bat, kodwa ibophe kancinci kwi-ACE 2 receptors. Uphononongo olusebenzisa i-cryo-electron microscopy luveze umahluko intsholongwane-I-ACE 2 indawo yokubopha kwimeko yokubophelela kwe-NeoCoV kunye ne-PDF-2180-CoV kwi-ACE 2 receptors. Isichazi semolekyuli sichaphazela intsalela ye-Asp 338, ethintela i-NeoCoV ekubeni ibopheleleke kwi-ACE 2 receptor yomntu. Ukongeza, ukuguqulwa kwe-T510F kwimotif ebopha i-receptor ye-NeoCoV ibangela ukuba ibophe ngokufanelekileyo i-ACE 2 receptor.
Xa kujongwe izinga lokufa okuphezulu kwe-35% enxulumene ne-MERS-CoV enxulumene iintsholongwane Ithatyathwe kumnombo weBeta CoV, iNeoCoV inokubeka isoyikiso ekuveleni koxinzelelo oluphezulu lwe-NeoCoV kunye nePDF-2180-CoV (ekufumaneni uguquko lwe-T510F ngenxa ye-antigenic drift) enokubangela usulelo kunye nokufa ebantwini, kubi kakhulu. kunobhubhani wangoku. I-Antigenic drift ibhekiselele kwimfuza engaqhelekanga utshintsho oko kubangele utshintsho kwi protein isakhiwo, ngaloo ndlela iguqula amandla eprotheni okubopha kwi-receptor ethile. Ukongeza, usulelo olubangelwe lutshintsho lwe-T510F lwe-NeoCoV, alukwazanga ukunqunyulwa macala zii-antibodies ezijolise kwi-SARS-CoV-2 okanye i-MERS-CoV.
Uluntu lonke lwehlabathi lunethemba lokuba utshintsho kwi-NeoCoV kunye ne-PDF-2180-CoV ebangela ukuba ibopheleleke ngokufanelekileyo kwi-ACE 2 receptor yabantu, ihlala iluphononongo lwaselabhoratri ukuqonda ubungangamsha bezi zinto. iintsholongwane, kwaye ayibi yimeko yokudluliselwa kwe-zoonotic ukusuka kumalulwane ukuya ebantwini, kudala enye isiphithiphithi sehlabathi.
***
umthombo:
Yan H., okqhubekayo 2022. Izalamane ezisondeleyo ze-MERS-CoV kumalulwane zisebenzisa i-ACE2 njengezamkeli zabo ezisebenzayo. Shicilela kwangaphambili i-bioRxiv. Iposwe nge-25 kaJanuwari 2022. DOI: https://doi.org/10.1101/2022.01.24.477490
