I-COVID-19, ukungakhuseleki kunye nobusi: Inkqubela phambili yakutsha nje ekuqondeni iiPropathi zamayeza zeManuka Honey

Iipropathi ezilwa nentsholongwane ye-manuka yobusi kungenxa yobukho be-methylglyoxal (MG), i-arginine eqondiswe kwi-agent ye-glycating eguqula iziza ezikhona ngokukodwa kwi-SARS-CoV-2 genome, ngaloo ndlela iphazamisana nokuphindaphinda kwayo kunye nokuthintela intsholongwane. Ukongeza, ubusi be-manuka bukwabonisa iipropathi ezinamandla ezichasayo kunye ne-anti-cancer. Okwangoku, ubusi be-manuka bunokuba yi-ambrosia enokuthi isetyenziselwe ukomeleza ukhuseleko losulelo, kubandakanya i-COVID-19. ngokwenjenjalo kukhuthazwa impilo.

Kwimozulu yangoku Covid-19 ubhubhane ngakumbi xa i-SARS-CoV-2 iguquka ngesantya esonyukayo, inika ulwahlulo olosulelayo oluphakamisa inkxalabo, kunokuba yimfuneko ukuphonononga kunye nokunyusa izixhobo ezinokuthi zibenakho ukomeleza ukhuseleko kunye negalelo ekulweni ngokuchaseneyo. Covid-19 ukunciphisa ukugula nokufa, ngaloo ndlela kuphuculwe impilo.  

Ukongeza kusetyenziso lwe Vitamin C kunye no-D ukomeleza amajoni omzimba, ubusi, ngakumbi ubusi beMānuka (ubusi bemonofloral obuveliswe kwincindi yomthi wemānuka, Leptospermum scoparium  iinyosi zobusi zaseYurophu (i-apis mellifera) Kuqondwa njengokubonelela ngezibonelelo zempilo njenge-immune booster malunga nokulwa nosulelo. Eli nqaku liza kuhlalutya, liphonononge kwaye livavanye ubungqina obuvela kuphando lwakutsha nje malunga nobusi be-manuka kunye neempawu zayo zonyango. Ubusi beManuka benziwe ngeentyatyambo zomthi we-manuka ukuba yinzalelwane yase-Australia naseNew Zealand. 

Inxalenye enkulu ye-manuka yobusi ejongene ne-antibacterial kunye ne-anti-viral properties kubukho bexabiso eliphezulu le-methylglyoxal (MG). Ngelixa i-MG ikhona kuzo zonke iintlobo zobusi kwiimpawu ezihlukeneyo, ikhona kwi-concentration ephezulu kakhulu kwi-manuka honey. Iziphumo eziphakamileyo zeMG ukusuka kukuguqulwa kwe-dihydroxyacetone ekhoyo kwiintyatyambo zomthi we-manuka kwindawo ephezulu. Iphezulu iMG, iphezulu isiphumo se-antibiotic. Ubusi be-Manuka bulinganiswa kusetyenziswa into yokulinganisa eyaziwa ngokuba yi-UMF (i-Unique Manuka Factor). Ephakamileyo i-UMG, iphakamisa iipropathi ze-antibiotic ye-manuka honey kwaye inyuse ixabiso layo. 

Kuye kwaboniswa ukuba i-MG, ekhoyo ekugxininiseni okubalulekileyo kwi-manuka yobusi, inokusebenza njenge-arginine-directed glycating agent, kwi-toxicity ekhethiweyo. SARS-selwe-2. Uhlalutyo lokulandelelana kwe-SARS-CoV-2 proteome lubonakalise ubukho bokutyetyiswa okuphindwe ka-5 kwe-methylglyoxal indawo yohlengahlengiso kwi-SARS-CoV-2 proteome, xa kuthelekiswa nomkhosi womntu - ebonisa ubutyhefu obukhethiweyo be-methylglyoxal kwintsholongwane. ⁽¹⁾. Ubusi beManuka bunokuphazamisa ukuphindaphinda kwentsholongwane kwaye buthintele ukukhula kwentsholongwane egutyungelweyo ⁽²⁾. Iimpembelelo ze-anti-viral kunye ne-immunomodulatory zobusi be-manuka nazo zingabalelwa kubukho beekhompawundi ze-phenolic ezisebenza njenge-anti-oxidants. ⁽³⁾. Ubukho be-phenolic compounds, i-flavonoids efana ne-quercetin inokuthintela i-3-chymotrypsin-like cysteine ​​protease, i-enzyme edlala indima ebalulekileyo kumjikelezo wobomi bentsholongwane. ⁽⁴⁾, ngokubonisa anti-wentsholongwane iziphumo zobusi be-manuka. 

Ipropathi ye-antibacterial ye-manuka yobusi ivela kubukho be-Hydrogen peroxide, i-pH ephantsi kunye nomxholo ophezulu weswekile, iimpawu ezifumaneka kwezinye iintlobo zobusi ngokunjalo. Impembelelo ye-antibacterial yobusi be-manuka ibonakaliswe ngokunciphisa kakhulu ukusebenza kweseli ye-MRSA kwi-biofilm. ⁽⁵⁾. Oku kwaba ngenxa yokuncipha kakhulu kokubonakaliswa kwemfuza ekhowudiweyo i-lamini- (ikaelastin- (ebps) kunye neprotheyini yokubopha i-fibrinogen (umtya), Kunye icaA kwaye icaD, inxaxheba kwi-biosynthesis ye-polysaccharide intercellular adhesin kuzo zombini ezibuthathaka kwaye zibambelela ngokuqinileyo, xa kuthelekiswa nolawulo. Ubusi be-Manuka buphinde bubonise umsebenzi ochasene ne-Escherichia coli O157: H7 kwi-biofilms ⁽⁶⁾ kunye nomsebenzi wokwenziwa kwe-bactericidal kunye ne-anti-spore ngokuchasene Clostridioides difficile  ⁽⁷⁾. 

Ukongeza, ubusi be-manuka bukwabonakaliswe ukubonisa umsebenzi wokuchasana nomhlaza. Oku kubonakaliswe ngokukwazi kwe-manuka yobusi ukukhuthaza i-apoptosis kumgca weseli yomhlaza ngokugcina ukufikeleleka okuphezulu kwe-hydrogen peroxide ngokuchasene ne-intracellular reactive oxygen. ⁽⁸⁾ . Impembelelo ye-antitumor yobusi be-manuka ngenxa yeziphumo zokuthintela kwi-inhibitory kunye nokubonakaliswa koxinzelelo lwe-oxidative kunye nokuthintela ukwanda kunye nemisebenzi yecandelo le-metastasis. ⁽⁹⁾. 

Kubonakala kukho ubungqina obaneleyo bokubonisa ukuba ukusetyenziswa kobusi, ngakumbi ubusi be-manuka kunokunceda abantu baphucule i-immunity yabo ngenxa yeempawu ezichasayo kunye ne-anti-bacterial ezibangelwa ubukho beMG. Ukongeza, ukusetyenziswa kobusi be-manuka njengenxalenye yolawulo lwendlela yokuphila kunokunceda ekuthinteleni umhlaza. Ngaba kufanelekile ukuqikelela ukuba ubusi be-manuka liyeza lazo zonke izifo ezithwaxa uluntu? Ixesha liya kuxela kwaye impendulo iya kulala kuhlalutyo lwedatha eveliswe kwizifundo ezininzi malunga nokusetyenziswa kobusi be-manuka. Nangona kunjalo, okwangoku, ubusi be-manuka bubonakala ngathi yi-ambrosia enokuthi isetyenziswe kwiipropathi zayo zonyango ukunqanda ubunzulu bosulelo lwebhaktheriya kunye nentsholongwane. Covid-19. 

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Ucaphulo 

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