Kuyaziwa ukuba Covid-19 kwandisa umngcipheko we ukuhlaselwa yintliziyo, stroke, kunye Long Covid kodwa into ebingaziwa kukuba ingaba umonakalo uyenzeka na ngenxa yokuba intsholongwane yosulela izicubu zentliziyo ngokwayo, okanye ngenxa yenkqubo ukukrala ziqaliswe yindlela yokusabela komzimba kwintsholongwane. Kuphononongo olutsha, abaphandi bafumanise ukuba usulelo lwe-SARS-CoV-2 lonyuse inani lilonke lee-macrophages zentliziyo kwaye zabangela ukuba basuke kumsebenzi wabo wesiqhelo babe nokudumba. I-macrophages yentliziyo evuthayo iyonakalisa intliziyo kunye nomzimba wonke. Abaphandi bafumanise ukuba ukuthintela impendulo yomzimba yokuzikhusela nge-antibody engathathi hlangothi kwimodeli yezilwanyana kumise ukuhamba kwentliziyo evuthayo. macrophages kunye nokusebenza kwentliziyo egciniweyo ebonisa le ndlela inamandla onyango.
Kuyaziwa ukuba i-COVID-19 yonyusa umngcipheko wokuhlaselwa yintliziyo, ukubetha, kunye ne-Long COVID. Ngaphezu kwe-50% yabantu abafumana i-COVID-19 bafumana ukudumba okanye ukonakala kwentliziyo. Into ebingaziwa yeyokuba ingaba umonakalo wenzeka na ngenxa yokuba intsholongwane yosulela izicubu zentliziyo ngokwayo, okanye ngenxa yokudumba kwenkqubo okubangelwa kukusabela komzimba kwintsholongwane.
Uphononongo olutsha lunika ukukhanya kwikhonkco phakathi kokwenzakala okumandundu kwemiphunga kwi-COVID-19 eqatha kunye nokudumba okunokukhokelela kwiingxaki zentliziyo. Uphononongo lugxininise kwiiseli ze-immune ezibizwa ngokuba yi-macrophages ye-cardiac, ngokuqhelekileyo yenza indima ebalulekileyo ekugcineni izicubu ziphilile kodwa zibe zivutha ekuphenduleni ukulimala okufana nokuhlaselwa kwentliziyo okanye ukungaphumeleli kwentliziyo.
Abaphandi bahlalutya iisampulu zeethishu zentliziyo kwizigulana ezingama-21 ezibhubhe ngenxa ye-SARS-CoV-2-enxulumene ne-acute respiratory distress syndrome (ARDS) kwaye bazithelekisa nemizekelo yezigulana ezingama-33 ezibhubhe ngenxa yezizathu ezingezizo i-COVID-19. Ukulandela okwenzekileyo kwi-macrophages emva kosulelo, abaphandi nabo bosulela iimpuku I-SARS-CoV-2.
Kwafunyaniswa ukuba usulelo lwe-SARS-CoV-2 lonyuse inani elipheleleyo lee-macrophages zentliziyo ebantwini nakwiimpuku. Usulelo luye lwabangela ukuba i-macrophages ye-cardiac itshintshe ukusuka kumsebenzi wabo wesiqhelo ukuze ibe nokudumba. I-macrophages evuthayo iyonakalisa intliziyo kunye nomzimba wonke.
Uphononongo lwenziwe kwiimpuku ukuvavanya ukuba impendulo abayibonileyo yenzekile na ngenxa yokuba i-SARS-CoV-2 yayiyosulela intliziyo ngokuthe ngqo, okanye ngenxa yokuba usulelo lwe-SARS-CoV-2 emiphungeni lwalungqongqo ngokwaneleyo ukunika intliziyo i-macrophages ngakumbi. Olu phononongo lulinganise iimpawu zokudumba kwemiphunga, kodwa ngaphandle kobukho bentsholongwane yokwenyani. Kwafunyaniswa ukuba nangona intsholongwane ingekho, iimpuku zabonisa iimpendulo zomzimba zomelele ngokwaneleyo ukuba zivelise inguqu efanayo ye-macrophage yentliziyo eyabonwa kwizigulana ezibhubhe yi-COVID-19 kunye neempuku ezosulelwe yi-SARS-CoV-2. .
Intsholongwane ye-SARS-CoV-2 yonakalisa ngokuthe ngqo izicubu zemiphunga. Emva kwe-a Covid usulelo, ukongeza kumonakalo othe ngqo yintsholongwane, amajoni omzimba anokonakalisa amanye amalungu ngokubangela ukudumba okuqinileyo kuwo wonke umzimba.
Okubangel 'umdla kukuba, kwafunyaniswa ukuba ukuthintela impendulo yokuzivikela komzimba kunye ne-antibody engathathi hlangothi kwiimpuku kumise ukuhamba kwe-macrophages ye-cardiac evuthayo kunye nokugcina umsebenzi wentliziyo. Oku kubonisa ukuba le ndlela (oko kukuthi ukucinezela ukudumba kunokunciphisa iingxaki) inamandla onyango ukuba ifunyenwe ikhuselekile kwaye iyasebenza kwiimvavanyo zekliniki.
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Iingxelo:
- NIH. Ukukhutshwa kweendaba-Usulelo oluqatha lwemiphunga ngexesha le-COVID-19 lunokubangela umonakalo entliziyweni. Ithunyelwe nge-20 Matshi 2024. Ifumaneka apha https://www.nih.gov/news-events/news-releases/severe-lung-infection-during-covid-19-can-cause-damage-heart
- Grune J., okqhubekayo 2024. I-Virus-Induced Acute Respiratory Distress Syndrome Ibangela I-Cardiomyopathy Ngokukhupha Iimpendulo ezivuthayo kwiNtliziyo. Ukujikeleza. 2024;0. Ipapashwe nge-20 Matshi 2024. DOI: https://doi.org/10.1161/CIRCULATIONAHA.123.066433
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