Ukuguqulwa kweSpike (S: L455S) luphawu lokuguqulwa kwe-JN.1 sub-yantlukwano ephucula ngokubonakalayo amandla ayo okukhusela amajoni omzimba okwenza ukuba aphephe ngokufanelekileyo uKlasi loku-1 lokungathinteli izilwa-buhlungu. Uphononongo luxhasa ukusetyenziswa kwezitofu ezihlaziyiweyo ze-COVID-19 ezineprotein ye-spike ukukhusela ngakumbi uluntu.
Ukungena ngaphakathi Covid-19 kuye kwachazwa iimeko kwiindawo ezininzi zehlabathi. Entsha i-sub-variant JN.1 (BA.2.86.1.1) eye yavela ngokukhawuleza ukusuka kwi-BA.2.86 yantlukwano kutshanje ibangele inkxalabo.
I-JN.1 (BA.2.86.1.1) i-sub-variant inotshintsho lwe-spike olongezelelweyo (S: L455S) xa kuthelekiswa ne-precursor yayo ye-BA.2.86. Olu lutshintsho oluphawulekayo lwe-JN.1 oluphucula ngokubonakalayo amandla ayo okuphepha amajoni omzimba okuyenza ikwazi ukubaleka ngokusebenzayo izilwa-buhlungu zoMgangatho woku-1. I-JN.1 ikwagcina iinguqu ezintathu kwiiprotheni ezingezizo ze-S. Ngokubanzi, i-JN.1 iye yanda ukudluliselwa kunye nokukwazi ukuphuma komzimba1,2.
Ugonyo lwe-COVID-19 luhambe umgama omde ukusukela ubhubhane kwaye luhlaziywe ngokubhekisele kwiprotein ye-spike ukuhlangabezana nemiceli mngeni ebangelwe zizinto ezisanda kuvela ezahlukeneyo.
Uphononongo lwakutsha nje lucebisa ukuba i-monovalent ehlaziyiweyo ugonyo lwe-mRNA (I-XBB.1.5 MV) iyasebenza ekukhuliseni i-serum virus-neutralization antibodies ngokuphawulekayo ngokuchasene neendidi ezininzi eziquka ngokuchasene ne-JN.1. Olu phononongo luxhasa ukusetyenziswa kwezitofu ezihlaziyiweyo ze-COVID-19 ezineprotein ye-spike ukukhusela ngakumbi uluntu3.
Ukuba i-JN.1 i-sub-variant ibonisa ingozi eyongeziweyo kwimpilo yoluntu ngokunxulumene nezinye iinguqulelo ezijikelezayo ngoku, i-CDC ithi abukho ubungqina4.
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Iingxelo:
- Yang S., okqhubekayo 2023. Ukuvela ngokukhawuleza kwe-SARS-CoV-2 BA.2.86 ukuya kwi-JN.1 phantsi koxinzelelo olunzima lomzimba. Shicilela kwangaphambili i-bioRxiv. Ithunyelwe nge-17 kaNovemba 2023. DOI: https://doi.org/10.1101/2023.11.13.566860
- Kaku Y., okqhubekayo 2023. Iimpawu zeVirological zokwahluka kwe-SARS-CoV-2 JN.1. Shicilela kwangaphambili i-bioRxiv. Ithunyelwe nge-09 kaDisemba 2023. DOI: https://doi.org/10.1101/2023.12.08.570782
- Wang Q. okqhubekayo 2023. I-XBB.1.5 i-monovalent ye-mRNA yokukhuthaza isitofu yenza izilwa-buhlungu ezomeleleyo ezingathinteliyo ngokuchasene nokwahluka okuvelayo kwe-SARS-CoV-2. Shicilela kwangaphambili i-bioRxiv. Ithunyelwe nge-06 kuDisemba 2023. DOI: https://doi.org/10.1101/2023.11.26.568730
- Iziko Lolawulo Lwesifo. Uhlaziyo kwi-SARS-CoV-2 Ukwahluka kwe-JN.1 Kulandelwa yi-CDC. Ifumaneka e https://www.cdc.gov/respiratory-viruses/whats-new/SARS-CoV-2-variant-JN.1.html
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