IGF-1: Ukurhweba phakathi koMsebenzi woQoqosho kunye noMngcipheko woMhlaza

I-Insulin-like growth factor 1 (IGF-1) yinto ebalaseleyo yokukhula eqhuba uninzi lweziphumo zokukhuthaza ukukhula kwe-growth hormone (GH) ngokuvuselela kwe-GH ukukhululwa kwe-IGF-1 esibindini. ^1. I-IGF-1 signalling ikhuthaza ukukhula nokusasazeka komhlaza kwaye amayeza aye aphuhliswa ukujolisa kwi-IGF-1 receptor (IGF1R) ukunciphisa i-IGF-1 signalling, nangona ingasebenzi ngenxa yokuxhathisa amayeza aphuhliswayo kwizigulane ^2. I-IGF-1 ikhethwe njengengxaki yomhlaza weprostate kwaye amanqanaba aphezulu e-serum ye-IGF-1 anxulunyaniswa neentlobo ngeentlobo zomhlaza ^2. Nangona kunjalo, ngenxa yeziphumo zayo zokukhuthaza ukukhula, kuquka nasebuchotsheni, ukuncipha kwe-IGF-1 signaling engqondweni kunxulunyaniswa nesifo sika-Alzheimer (AD) esonyukayo kunye nomngcipheko we-dementia, ukwehla kwengqondo, ixhala kunye nokudakumba ² okubonisa ukurhweba phakathi komsebenzi wokuqonda kunye nomngcipheko womhlaza.

Iimpuku ezine-serum IGF-1 ephantsi zineengxaki zokuqonda ezithi zijike xa i-IGF-1 inikwa iimpuku ^2. Zombini i-insulin receptor (IR) kunye ne-IGF1R zivuselela ukwahlukana kweeseli kwaye ke ngoko nokukhula komhlaza ^2. Ukufunda kunye nenkumbulo kufuna i-insulin/IGF-1 signaling kwaye ukwanda kwe-IGF-1 kwakuhambelana nokuphucuka kwenkumbulo kunye nokwanda komthamo we-hippocampus ^2. Ngaphezu koko, kwizigulane zesifo sikaParkinson (PD) ezazinamanqanaba aphantsi e-serum IGF-1, zazingasebenzi kakuhle kwimisebenzi evavanya umsebenzi wokuqonda ^2. Nangona kunjalo, okunomdla kukuba i-IGF-1 inokucothisa ukususwa kwe-beta-amyloid plaque enegalelo kwi-AD ² , kodwa kubonakala ngathi kubungqina bokuba i-IGF-1 ngokubanzi ikhusela kakhulu ukuqonda, ikhusela i-neurogenesis kwaye ikhusela i-neuroprotective.

Umzekelo ocacileyo wolu tshintsho kukunciphisa umngcipheko we-AD phakathi kwezigulane ezinomhlaza , kunye nokuba izigulane ezindala ezinomhlaza zinememori ephezulu kunye nesantya esiphantsi sokuwohloka komsebenzi wememori ^2. Ke ngoko, kubonakala kukhuselekile ukucinga ukuba i-IGF-1 , njengezinye izinto ezininzi, ineenzuzo kunye neengozi ezinxulumene nayo kwaye akukho ndlela ilula yokuba "sempilweni" ngokulawula i-IGF-1 ngokutshintsha indlela yokuphila efana nokuzila ukutya kunye nokunciphisa amandla ukuze kuncitshiswe uxinano lwayo kwi-serum, njengoko ukunciphisa uxinano kwi-serum kunokuba nemiphumo engalindelekanga engqondweni eyenza umntu "angabi sempilweni" ngokwengqondo.

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Iingxelo:  

1. ULaron Z. (2001). I-insulin-efana ne-insulin factor 1 (IGF-1): i-hormone yokukhula. I molecular i-pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311 

2. I-Rosenzweig SA (2020). I-Evolution eqhubekayo ye-Insulin-like Growth Factor Signaling. F1000 Uphando, 9, F1000 Faculty Rev-205. https://doi.org/10.12688/f1000research.22198.1 

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