Uphononongo olucwangcisiweyo lubonelela ngobungqina obubanzi bokuba ukulawula i-microbiota emathunjini kunokuba yindlela enokwenzeka yokuthomalalisa iimpawu zokuxhalaba.
Iintsholongwane zethu zamathumbu – iitriliyoni zeentsholongwane zendalo ezisemathunjini – zaziwa ngokuba nendima ebalulekileyo ekukhuseleni amasosha omzimba, imetabolism kunye nempilo yengqondo. Izifundo ezininzi zibonise ukuba iintsholongwane zamathumbu zinokulawula iindlela zokusebenza kwengqondo. Ixhala – ixhala elikhulu, eligqithisileyo nelihlala lihleli kunye noloyiko lweziganeko okanye iimeko – liqhelekile kwiingxaki zengqondo kunye neengxaki ezininzi zomzimba xa kubandakanyeke uxinzelelo. Iimpawu zexhala ziquka ukuziva unexhala, uxinezelekile, ukunyuka kwesantya sentliziyo kunye nokuphefumla, ukubila, ukungalali njl. Ukungalingani kweentsholongwane ze-intestinal microbiota kuye kwanxulunyaniswa nexhala nangona ubungqina obuthe ngqo bokuphucuka kweempawu zexhala ngokulawula le microbiota abufumanekanga.
Kuphononongo olutsha olucwangcisiweyo olupapashwe ngoMeyi 17 kwi- BMJ General Psychiatry, iqela labaphandi lihlolisise kuphela iimvavanyo ezilawulwa ngokungacwangciswanga ebantwini ezipapashwe ngaphambili ngenjongo yokuphanda ubungqina bokuba iimpawu zokuxhalaba zinokuphucuka ngokulawula iintsholongwane emathunjini. Bahlolisise iincwadi ezidlulileyo baza bafumana amanqaku angama-3334 kwiidathabheyisi ezintlanu zesiNgesi nezine zesiTshayina baza badwelisa izifundo ezingama-21. Uvavanyo olucwangcisiweyo lwezifundo ezingama-21 ezazihlalutye ngokudibeneyo malunga nabantu abayi-1500 lwaqhutywa. Abantu ababeneempawu zokuxhalaba ezilinganiswe kwizikali zokuxhalaba nokuba baxilongwe kangakanani na. Zonke izifundo zisebenzise iindlela zokungenelela ukulawula i-intestinal microbiota (IRIFs) ezibandakanya izongezo ze-probiotic okanye utshintsho lokutya . Ezili-14 kwezi zifundo zisebenzise ii-probiotics njengongenelelo ngelixa zisala utshintsho olusetyenzisiweyo ekutyeni komntu kwemihla ngemihla. Ii-Probiotics zizongezo zokutya eziqulethe iintsholongwane "ezilungileyo" ezinokulwa neentsholongwane "eziyingozi" kwaye mhlawumbi zingazivumeli ukuba zihlale emathunjini. Ngaphandle koko, ukutya ukutya okusekwe kwizityalo okutyebileyo kwifayibha kunokunyusa iintsholongwane ezilungileyo emathunjini. Isiphumo sophando ngalunye sivavanywe ngokulinganisa iimpawu zokuxhalaba kusetyenziswa izikali zovavanyo lokuxhalaba ezisemgangathweni.
Uhlalutyo lubonise ukuba kwizifundo ezili-11 kwezingama-21, isiphumo sokunciphisa sibonwe kwiimpawu zokuxhalaba ngenxa yokulawulwa kwe-intestinal microbiota ebonisa ukusebenza kakuhle phantse kwiipesenti ezingama-52 zezifundo. Kwizifundo ezili-14 ezisebenzise izongezo ze-probiotics njengokungenelela, izifundo ezingama-36 ekhulwini zifumanise ukuba ukulawulwa kwe-regulation sisixhobo esisebenzayo ekunciphiseni iimpawu. Okokugqibela, kwizifundo ezi-6 kwezi-7 ezisebenzise iindlela zokungenelela ezingezizo iiprobiotics , ukusebenza kakuhle kubonwe kuma-86 ekhulwini. Kwizifundo ezi-5 ezisebenzise indlela yokungenelela ye-IRIF kunye nonyango oluqhelekileyo, kuphela izifundo ezisebenzisa iindlela zokungenelela ezingezizo iiprobiotics ezifumene iziphumo ezilungileyo ezibonisa ukuba ukungenelela okungezizo iiprobiotic kunye ne-IRIF kusebenza ngakumbi kune-IRIF yodwa. Ukutshintsha ukutya komntu kunokuba nefuthe elikhulu kwiibhaktheriya zamathumbu xa kuthelekiswa nokongezwa kweentlobo ezithile zeebhaktheriya ezityiwa nge-probiotic supplement. Akukho ziganeko zimbi zibikiweyo kwizifundo ezininzi, kuphela umlomo owomileyo, ukungonwabi okanye urhudo.
Ubuncinane isiqingatha sezifundo ezivavanyiweyo zibonise ukuba ukuguqula i-microbiota emathunjini kunokunyanga iimpawu zokuxhalaba kwizigulana nokuba zixilongiwe na. Kwaye, indlela engeyiyo i-probiotics ngokwenza uhlengahlengiso olufanelekileyo lokutya yayisebenza ngakumbi xa ithelekiswa neendlela zokungenelela ze-probiotic. Kunyango lwezonyango lokuxhalaba , kusetyenziswa amayeza engqondo. Kungenjalo, xa izigulana zingafaneleki ukufumana amayeza anjalo - ingakumbi xa zinezifo zomzimba - iindlela zokungenelela ze-probiotic okanye ezingezizo ze-probiotic zinokusetyenziswa ukunyanga ukuxhalaba.
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{Unokufunda iphepha lokuqala lophando ngokunqakraza ikhonkco le-DOI elinikwe ngezantsi kuluhlu lwemithombo ecatshulweyo (s)}
Umthombo (s)
UYang B. et al. 2019. Iziphumo zokulawula i-intestinal microbiota kwiimpawu zokuxhalaba : Uphononongo olucwangcisiweyo. Ingqondo Jikelele. http://dx.doi.org/10.1136/gpsych-2019-100056
